Findings

What do systematic reviews say?

20 questions · 20 findings · 2 reviews · Infectious Diseases · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 9 · 45%Low 6 · 30%Moderate 5 · 25%High 0 · 0%

Zinc vs placebo

Change in blood zinc concentrations · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 484 participants
Moderate

Zinc vs placebo

All‐cause mortality · adults with HIV infection

It is very uncertain whether zinc changes mortality compared with placebo (very low certainty).

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
RR 1.24 [0.53, 2.86]
3 studies · 433 participants
Very low

Zinc vs placebo

Rate of diarrhoea · adults with HIV infection

It is very uncertain whether zinc changes rate of diarrhoea compared with placebo (very low certainty).

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
OR 0.4 [0.18, 0.87]
1 study · 231 participants
Very low

Zinc vs placebo

Change in CD4 count · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 431 participants
Low

Zinc vs placebo

Change in viral load · adults with HIV infection

1 finding from 1 review

Micronutrient supplementation in adults with HIV infection 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 400 participants
Low

Intervention not reported

Duration of diarrhoea · children with acute diarrhoea

The intervention showed no clear difference in duration of diarrhoea (low certainty).

1 finding from 1 review

Oral zinc for treating diarrhoea in children 2016 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 2581 participants
Low

Intervention not reported

Adverse events (vomiting) · children aged less than 6 months with acute diarrhoea

The intervention probably leads to higher adverse events (vomiting) (moderate certainty).

1 finding from 1 review

Oral zinc for treating diarrhoea in children 2016 · Cochrane Headline outcomes only
RR 1.54 [1.05, 2.24]
2 studies · 1334 participants
Moderate

Intervention not reported

Duration of diarrhoea · children with persistent diarrhoea

The intervention showed no clear difference in duration of diarrhoea (moderate certainty).

1 finding from 1 review

Oral zinc for treating diarrhoea in children 2016 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 529 participants
Moderate

Intervention not reported

Diarrhoea on day 7 · children with persistent diarrhoea

The intervention showed no clear difference in diarrhoea on day 7 (low certainty).

1 finding from 1 review

Oral zinc for treating diarrhoea in children 2016 · Cochrane Headline outcomes only
RR 0.52 [0.27, 1.02]
2 studies · 221 participants
Low

Intervention not reported

Hospitalization · children with persistent diarrhoea

1 finding from 1 review

Oral zinc for treating diarrhoea in children 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 275 participants
Very low

Intervention not reported

Death · children with persistent diarrhoea

1 finding from 1 review

Oral zinc for treating diarrhoea in children 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 402 participants
Very low

Intervention not reported

Adverse events (vomiting) · children with persistent diarrhoea

It is very uncertain whether the intervention changes adverse events (vomiting) (very low certainty).

1 finding from 1 review

Oral zinc for treating diarrhoea in children 2016 · Cochrane Headline outcomes only
RR 1.97 [0.37, 10.59]
4 studies · 505 participants
Very low

Intervention not reported

Diarrhoea on day 7 · children with acute diarrhoea

The intervention probably leads to lower diarrhoea on day 7 (moderate certainty).

1 finding from 1 review

Oral zinc for treating diarrhoea in children 2016 · Cochrane Headline outcomes only
RR 0.73 [0.61, 0.88]
6 studies · 3865 participants
Moderate

Intervention not reported

Number of children hospitalized (community trials only) · children with acute diarrhoea

1 finding from 1 review

Oral zinc for treating diarrhoea in children 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 276 participants
Very low

Intervention not reported

Death · children with acute diarrhoea

It is very uncertain whether the intervention changes death (very low certainty).

1 finding from 1 review

Oral zinc for treating diarrhoea in children 2016 · Cochrane Headline outcomes only
RR 0.29 [0.04, 2.2]
4 studies · 1134 participants
Very low

Intervention not reported

Adverse events (vomiting) · children with acute diarrhoea

The intervention probably leads to higher adverse events (vomiting) (moderate certainty).

1 finding from 1 review

Oral zinc for treating diarrhoea in children 2016 · Cochrane Headline outcomes only
RR 1.57 [1.32, 1.86]
6 studies · 2605 participants
Moderate

Intervention not reported

Duration of diarrhoea · children aged less than 6 months with acute diarrhoea

The intervention showed no clear difference in duration of diarrhoea (low certainty).

1 finding from 1 review

Oral zinc for treating diarrhoea in children 2016 · Cochrane Headline outcomes only
MD 5.23
2 studies · 1334 participants
Low

Intervention not reported

Diarrhoea on day 7 · children aged less than 6 months with acute diarrhoea

The intervention showed no clear difference in diarrhoea on day 7 (low certainty).

1 finding from 1 review

Oral zinc for treating diarrhoea in children 2016 · Cochrane Headline outcomes only
RR 1.24 [0.99, 1.54]
1 study · 1074 participants
Low

Intervention not reported

Number of children hospitalized (community trials only) · children aged less than 6 months with acute diarrhoea

1 finding from 1 review

Oral zinc for treating diarrhoea in children 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1074 participants
Very low

Intervention not reported

Death · children aged less than 6 months with acute diarrhoea

It is very uncertain whether the intervention changes death (very low certainty).

1 finding from 1 review

Oral zinc for treating diarrhoea in children 2016 · Cochrane Headline outcomes only
RR 1 [0.06, 15.89]
2 studies · 1334 participants
Very low