Findings

What do systematic reviews say?

63 questions · 65 findings · 7 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 40 · 61.5%GRADE not reported 1 · 1.5%Very low 9 · 13.8%Low 11 · 16.9%Moderate 4 · 6.2%High 0 · 0%

Vitamin D 100,000 IU/month vs 12,000 IU/month

Serum 25-hydroxyvitamin D level · people with sickle cell disease

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 57 participants
Low

Vitamin D vs placebo

Serum 25-hydroxyvitamin D level · people with sickle cell disease

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 37 participants
Moderate

Vitamin D vs placebo

Total body BMD measured by DEXA (% change from baseline) · people with sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin D vs placebo

Adverse events · people with sickle cell disease

Vitamin D showed no clear difference in adverse events compared with placebo (low certainty).

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
RR 3.16 [0.14, 72.84]
1 study · 37 participants
Low

Vitamin D vs placebo

Pain frequency or change in pain frequency · people with sickle cell disease

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 37 participants
Low

Vitamin D vs placebo

Acute chest syndrome ( · people with sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin D vs placebo

Respiratory infections · people with sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin D vs placebo

HRQoL score (physical functioning) (change from baseline) · people with sickle cell disease

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 37 participants
Low

Vitamin D 100,000 IU/month vs 12,000 IU/month

Adverse events · people with sickle cell disease

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Low

Vitamin D 100,000 IU/month vs 12,000 IU/month

Pain: presence of pain (slight or moderate) at 1 year · people with sickle cell disease

Vitamin D 100,000 IU/month showed no clear difference in presence of pain compared with 12,000 IU/month (moderate certainty).

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
RR 1 [0.62, 1.62]
1 study · 62 participants
Moderate

Vitamin D 100,000 IU/month vs 12,000 IU/month

Acute chest syndrome ( · people with sickle cell disease

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Moderate

Vitamin D 100,000 IU/month vs 12,000 IU/month

Respiratory infections · people with sickle cell disease

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Moderate

Vitamin D 100,000 IU/month vs 12,000 IU/month

HRQoL (using a validated scale) · people with sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin D 100,000 IU/month vs 12,000 IU/month

Total body BMD measured by DEXA (% change from baseline) · people with sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: fat‐soluble vitamin E vs control

Neuropathy due to vitamin E deficiency · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: fat‐soluble vitamin E vs control

Retinopathy due to vitamin E deficiency · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: fat‐soluble vitamin E vs control

Vitamin E total lipid ratio · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: fat‐soluble vitamin E vs control

Vitamin E levels in serum: umol/L · adults and children with cystic fibrosis

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
6 participants
GRADE not reported

Summary of findings: water‐soluble vitamin E vs control

Vitamin E total lipid ratio · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: water‐soluble vitamin E vs control

Vitamin E levels in serum: umol/L · adults and children with cystic fibrosis

Summary of findings: water‐soluble vitamin E may leads to higher vitamin E levels in serum: umol/L compared with control (low certainty).

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
MD 19.74 [13.48, 26]
1 study · 45 participants
Low