What do systematic reviews say?

Professionally-applied 12,300 ppm F APF foam, every 2 months vs 0 ppm F placebo foam

The review found no eligible studies for this question.

• Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes

  At debond (end of orthodontic treatment)
  SoF 2. Number of participants with more severe DLs: none of the trials reported this outcome.
  0 studies
  No studies found

Professionally-applied 12,300 ppm F APF foam, every 2 months vs 0 ppm F placebo foam

Professionally-applied 12,300 ppm F APF foam, every 2 months may leads to lower number of participants with new demineralised lesions (DLs) compared with 0 ppm F placebo foam (low certainty).

• Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes

  At debond; mean follow-up 18 months
  RR 0.26 [0.11, 0.57]
  1 study · 95 participants
  Low

Professionally-applied 12,300 ppm F APF foam, every 2 months vs 0 ppm F placebo foam

The review found no eligible studies for this question.

• Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes

  At debond (end of orthodontic treatment)
  SoF 2. Adverse effects: none of the trials reported this outcome.
  0 studies
  No studies found

Fluoride varnish vs Non-fluoride (placebo) varnish

Professionally-applied fluoride varnish (7700 or 10,000 ppm F),… showed no clear difference in number of participants with new demineralised lesions (DLs) compared with non-fluoride (placebo) varnish (low certainty).

• Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes

  At debond; follow-up 1.7 years
  RR 0.52 [0.14, 1.93]
  2 studies · 405 participants
  Low

Fluoride varnish vs Non-fluoride (placebo) varnish

• Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes

  At debond; follow-up 1.7 years
  SoF 1. Adverse effects: no evidence that the intervention had adverse effects; only 1 participant with an adverse event and unclear if directly related to the intervention. 148 participants (1 RCT, Sonesson 2019);…
  1 study · 148 participants
  Low

Fluoride varnish vs Non-fluoride (placebo) varnish

Professionally-applied fluoride varnish (7700 ppm F ammonium… may leads to lower number of participants with more severe DLs (score 3 or 4 versus 1… compared with non-fluoride (placebo) varnish (low certainty).

• Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes

  At debond; follow-up 1.7 years
  RR 0.46 [0.22, 0.95]
  1 study · 148 participants
  Low

12,500 ppm F (NaF/olaflur/dectaflur) amine fluoride gel, professionally applied every 3 months plus home use vs Placebo gel

It is very uncertain whether 12,500 ppm F (NaF/olaflur/dectaflur) amine fluoride gel,… changes number of participants with new demineralised lesions (DLs) compared with 0 ppm F placebo gel (very low certainty).

• Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes

  At debond; mean follow-up 16.6 months
  RR 0.99 [0.76, 1.27]
  1 study · 312 participants
  Very low