Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 28.6%Low 2 · 28.6%Moderate 3 · 42.9%High 0 · 0%

Vasopressin receptor antagonists vs placebo or no treatment

Death · chronic non‐hypovolaemic hypotonic hyponatraemia

It is very uncertain whether vasopressin receptor antagonists changes death compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Interventions for chronic non‐hypovolaemic hypotonic hyponatraemia 2018 · Cochrane Headline outcomes only
RR 1.11 [0.92, 1.33]
15 studies · 2330 participants
Very low

Vasopressin receptor antagonists vs placebo or no treatment

Health‐related quality of life ( · chronic non‐hypovolaemic hypotonic hyponatraemia

1 finding from 1 review

Interventions for chronic non‐hypovolaemic hypotonic hyponatraemia 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 297 participants
Very low

Vasopressin receptor antagonists vs placebo or no treatment

Length of hospital stay · chronic non‐hypovolaemic hypotonic hyponatraemia

1 finding from 1 review

Interventions for chronic non‐hypovolaemic hypotonic hyponatraemia 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 580 participants
Low

Vasopressin receptor antagonists vs placebo or no treatment

Cognitive function · chronic non‐hypovolaemic hypotonic hyponatraemia

1 finding from 1 review

Interventions for chronic non‐hypovolaemic hypotonic hyponatraemia 2018 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1169 participants
Low

Vasopressin receptor antagonists vs placebo or no treatment

Change from baseline in serum sodium concentration · chronic non‐hypovolaemic hypotonic hyponatraemia

1 finding from 1 review

Interventions for chronic non‐hypovolaemic hypotonic hyponatraemia 2018 · Cochrane Headline outcomes only
no estimate extracted
21 studies · 2641 participants
Moderate

Vasopressin receptor antagonists vs placebo or no treatment

Serum sodium concentration (response) · chronic non‐hypovolaemic hypotonic hyponatraemia

Vasopressin receptor antagonists probably leads to higher serum sodium concentration (response) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Interventions for chronic non‐hypovolaemic hypotonic hyponatraemia 2018 · Cochrane Headline outcomes only
RR 2.49 [1.95, 3.18]
18 studies · 2104 participants
Moderate

Vasopressin receptor antagonists vs placebo or no treatment

Rapid sodium increase · chronic non‐hypovolaemic hypotonic hyponatraemia

Vasopressin receptor antagonists probably leads to higher rapid sodium increase compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Interventions for chronic non‐hypovolaemic hypotonic hyponatraemia 2018 · Cochrane Headline outcomes only
RR 1.67 [1.16, 2.4]
14 studies · 2058 participants
Moderate