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Evidence found and GRADE certainty

3 questions · 5 findings · 1 reviews · All outcomes

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No studies found 0 · 0%GRADE not reported 1 · 20%Very low 4 · 80%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Closest answers

The findings closest to your search, judged one by one by TypeSafe's Jev model.

  • Direct match · question page
    • Vasodilators (isoxsuprine, xanthinol nicotinate) vs Placebo or no active treatment · Maximal mouth opening (interincisal distance)
      Interventions for managing oral submucous fibrosis 2024 · Cochrane All outcomes
      3 to 6 months
      MD 4.04 [-1.93, 10.02]
      2 studies · 85 participants
      Very low
  • Direct match · question page
    • Vasodilators (isoxsuprine, xanthinol nicotinate) vs Placebo or no active treatment · Burning sensation (VAS 0-100)
      Interventions for managing oral submucous fibrosis 2024 · Cochrane All outcomes
      3 to 6 months
      MD -51.02 [-72.85, -29.20]
      2 studies · 85 participants
      Very low
  • Direct match · question page
    • Vasodilators (isoxsuprine, xanthinol nicotinate) vs Placebo or no active treatment · Adverse effects
      Interventions for managing oral submucous fibrosis 2024 · Cochrane All outcomes
      Adverse effects (any): 0 placebo vs 14 minor (transient flushing and upper trunk warmness); 85 (2); no GRADE rating.
      2 studies · 85 participants
      GRADE not reported

Vasodilator vs Placebo or no active treatment

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether vasodilators (isoxsuprine, xanthinol nicotinate) changes maximal mouth opening (interincisal distance) compared with placebo or no active treatment (very low certainty).

2 findings from 1 review

Vasodilator vs Placebo or no active treatment

Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether vasodilators (isoxsuprine, xanthinol nicotinate) changes burning sensation (VAS 0-100) compared with placebo or no active treatment (very low certainty).

2 findings from 1 review