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Evidence found and GRADE certainty

155 questions · 173 findings · 22 reviews · Heart

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No studies found 32 · 18.5%GRADE not reported 1 · 0.6%Very low 38 · 22%Low 66 · 38.2%Moderate 30 · 17.3%High 6 · 3.5%

Advance care planning vs usual care

Concordance between participants' preferences and end‐of‐life care (yes/no) Post‐death data: mean days to death, ACP group (388.8 ± 255.7); usual care group (362.2 ± 288.4) · people with heart failure with or without their surrogate decision‐makers/carers

It is very uncertain whether advance care planning changes concordance between participants' preferences and end‐of‐life care… compared with usual care (very low certainty).

1 finding from 1 review

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Cardiovascular mortality · adults (≥ 18 years of age) with a diagnosis of chronic heart failure with reduced ejection fraction (HFrEF)

Usual care with ivabradine showed no clear difference in mortality from cardiovascular causes ( compared with placebo, usual care, or no treatment (moderate certainty).

2 findings from 1 review

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Time to first hospitalisation for heart failure during · adults (≥ 18 years of age) with a diagnosis of chronic heart failure with reduced ejection fraction (HFrEF)

The review found no eligible studies for this question.

2 findings from 1 review

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Number of days spent in hospital due to heart failure during · adults (≥ 18 years of age) with a diagnosis of chronic heart failure with reduced ejection fraction (HFrEF)

The review found no eligible studies for this question.

2 findings from 1 review

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Rate of serious adverse events · adults (≥ 18 years of age) with a diagnosis of chronic heart failure with reduced ejection fraction (HFrEF)
2 findings from 1 review

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Exercise capacity · adults (≥ 18 years of age) with a diagnosis of chronic heart failure with reduced ejection fraction (HFrEF)
2 findings from 1 review

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Costs · adults (≥ 18 years of age) with a diagnosis of chronic heart failure with reduced ejection fraction (HFrEF)

The review found no eligible studies for this question.

2 findings from 1 review

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Cardiovascular mortality · patients with chronic heart failure with preserved ejection fraction
2 findings from 1 review

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Quality of life · patients with chronic heart failure with preserved ejection fraction
2 findings from 1 review

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Time to first hospitalisation for heart failure during · patients with chronic heart failure with preserved ejection fraction

The review found no eligible studies for this question.

2 findings from 1 review

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Number of days spent in hospital due to heart failure during · patients with chronic heart failure with preserved ejection fraction

The review found no eligible studies for this question.

2 findings from 1 review

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Rate of serious adverse events · patients with chronic heart failure with preserved ejection fraction
2 findings from 1 review

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Quality of life · adults (≥ 18 years of age) with a diagnosis of chronic heart failure with reduced ejection fraction (HFrEF)
2 findings from 1 review

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Exercise capacity · patients with chronic heart failure with preserved ejection fraction
2 findings from 1 review

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Costs · patients with chronic heart failure with preserved ejection fraction

The review found no eligible studies for this question.

2 findings from 1 review

Summary of findings ‐ structured telephone support or telemonitoring vs usual care

All‐cause mortality: Structured telephone support versus usual care · patients with heart failure

Summary of findings ‐ structured telephone support or telemonitoring probably leads to lower all‐cause mortality: Structured telephone support versus usual care compared with usual care ‐ all‐cause mortality (moderate certainty).

1 finding from 1 review

Summary of findings ‐ structured telephone support or telemonitoring vs usual care

Death (all causes) · patients with heart failure

Summary of findings ‐ structured telephone support or telemonitoring probably leads to lower all‐cause mortality: Telemonitoring versus usual care compared with usual care ‐ all‐cause mortality (moderate certainty).

1 finding from 1 review

Summary of findings ‐ structured telephone support or telemonitoring vs usual care ‐ all‐cause hospitalisation

Hospitalisation (any cause) · patients with heart failure

It is very uncertain whether summary of findings ‐ structured telephone support or telemonitoring changes all‐cause hospitalisation: Structured telephone support verus usual… compared with usual care ‐ all‐cause hospitalisation (very low certainty).

2 findings from 1 review

Summary of findings ‐ structured telephone support or telemonitoring vs usual care

Heart failure hospitalisation (RR) · patients with heart failure

Summary of findings ‐ structured telephone support or telemonitoring probably leads to lower CHF‐related hospitalisation: Structured telephone support versus… compared with usual care ‐ heart failure‐related hospitalisation (moderate certainty).

2 findings from 1 review