Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

83 questions · 83 findings · 4 reviews · Skin

No studies found 10 · 12%GRADE not reported 14 · 16.9%Very low 19 · 22.9%Low 18 · 21.7%Moderate 14 · 16.9%High 8 · 9.6%

Minoxidil vs placebo

Short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of · adults with alopecia areata

It is very uncertain whether summary of findings table ‐ Topical hair growth stimulants (minoxidil) changes short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Topical small molecule inhibitors (ruxolitinib) vs placebo

Short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of · adults with alopecia areata

Summary of findings table ‐ Topical small molecule inhibitors… showed no clear difference in short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of compared with placebo (low certainty).

1 finding from 1 review

Summary of findings table ‐ Topical small molecule inhibitors (ruxolitinib) vs placebo

Incidence of serious adverse events · adults with alopecia areata

It is very uncertain whether summary of findings table ‐ Topical small molecule inhibitors… changes incidence of serious adverse events compared with placebo (very low certainty).

1 finding from 1 review

Tavaborole 5% solution vs vehicle

Adverse events (directly related to treatment, collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails

Tavaborole 5% solution probably leads to higher adverse events (directly related to treatment, collected over the… compared with vehicle (moderate certainty).

1 finding from 1 review

P‐3051 (ciclopirox 8% hydrolacquer) vs comparators

Adverse events (collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails

P‐3051 (ciclopirox 8% hydrolacquer) showed no clear difference in adverse events (collected over the course of the studies; they are… compared with comparators (low certainty).

1 finding from 1 review

Nd:YAG laser vs no treatment/sham

Adverse events (collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails

It is very uncertain whether 1064‐nm Nd:YAG laser changes adverse events (collected over the course of the studies; they are… compared with no treatment or sham treatment (very low certainty).

1 finding from 1 review

Ciclopirox 8% lacquer vs vehicle

Adverse events (directly related to treatment, collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails

Ciclopirox 8% lacquer showed no clear difference in adverse events (directly related to treatment, collected over the… compared with vehicle (low certainty).

1 finding from 1 review