Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

17 questions · 17 findings · 3 reviews

No studies found 3 · 17.6%GRADE not reported 0 · 0%Very low 1 · 5.9%Low 11 · 64.7%Moderate 2 · 11.8%High 0 · 0%

Topical clindamycin vs placebo

Adverse effects (non‐serious) · participants with hidradenitis suppurativa

Topical clindamycin showed no clear difference in adverse effects (non‐serious) compared with placebo (moderate certainty).

1 finding from 1 review

Benzoyl peroxide vs clindamycin

Participant's global self‐assessment of improvement (long‐term data) · participants with acne

Benzoyl peroxide showed no clear difference in participant's global self‐assessment of improvement (long‐term data) compared with clindamycin (low certainty).

1 finding from 1 review

Benzoyl peroxide vs clindamycin

Adverse effects (side effects; treatment withdrawals) · participants with acne

It is very uncertain whether benzoyl peroxide changes withdrawal due to adverse effects (long‐term data) Treatment… compared with clindamycin (very low certainty).

1 finding from 1 review

Benzoyl peroxide vs clindamycin

Total number of participants with any adverse events (long‐term data) Treatment duration: range 10 weeks to 12 weeks · participants with acne

Benzoyl peroxide showed no clear difference in total number of participants with any adverse events (long‐term… compared with clindamycin (moderate certainty).

1 finding from 1 review

Nicotinamide vs clindamycin

Withdrawal for any reason (medium term: treatment duration from 5 to 8 weeks) · participants with acne

Nicotinamide showed no clear difference in withdrawal for any reason (medium term: treatment duration from 5 to… compared with clindamycin (low certainty).

1 finding from 1 review

Azelaic acid vs clindamycin

Participants' global self‐assessment of acne improvement Good or very good improvement (long term: treatment duration > 8 weeks) · participants with acne

Azelaic acid showed no clear difference in participants' global self‐assessment of acne improvement Good or… compared with clindamycin (low certainty).

1 finding from 1 review