Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 1 · 14.3%Very low 0 · 0%Low 0 · 0%Moderate 2 · 28.6%High 4 · 57.1%

Tocilizumab 8 mg/kg + MTX/DMARD vs placebo + DMARDs/biologic

ACR50% improvement criteria · patients with rheumatoid arthritis

Tocilizumab 8 mg/kg + MTX/DMARD leads to higher ACR50% improvement criteria compared with placebo + MTX/DMARD (high certainty).

1 finding from 1 review

Tocilizumab for rheumatoid arthritis 2010 · Cochrane Headline outcomes only
RR 3.17 [2.72, 3.67]
4 studies · 2063 participants
High

Tocilizumab 8 mg/kg + MTX/DMARD vs placebo + DMARDs/biologic

DAS (low or remission) · patients with rheumatoid arthritis

Tocilizumab 8 mg/kg + MTX/DMARD leads to higher DAS Remission defined as DAS28 <2.6 compared with placebo + MTX/DMARD (high certainty).

1 finding from 1 review

Tocilizumab for rheumatoid arthritis 2010 · Cochrane Headline outcomes only
RR 8.74 [6.26, 11.8]
4 studies · 1946 participants
High

Tocilizumab 8 mg/kg + MTX/DMARD vs placebo + DMARDs/biologic

HAQ improvement of >0.3 or MHAQ decrease of >0.22 (changes exceeding MCID) · patients with rheumatoid arthritis

Tocilizumab 8 mg/kg + MTX/DMARD leads to higher HAQ improvement of >0.3 or MHAQ decrease of >0.22 (changes exceeding… compared with placebo + MTX/DMARD (high certainty).

1 finding from 1 review

Tocilizumab for rheumatoid arthritis 2010 · Cochrane Headline outcomes only
RR 1.79 [1.62, 1.94]
1 study · 1220 participants
High

Tocilizumab 8 mg/kg + MTX/DMARD vs placebo + DMARDs/biologic

Serious adverse events · patients with rheumatoid arthritis

Tocilizumab 8 mg/kg + MTX/DMARD showed no clear difference in serious Adverse Events compared with placebo + MTX/DMARD (moderate certainty).

1 finding from 1 review

Tocilizumab for rheumatoid arthritis 2010 · Cochrane Headline outcomes only
RR 1.17 [0.83, 1.64]
3 studies · 1961 participants
Moderate

Tocilizumab 8 mg/kg + MTX/DMARD vs placebo + DMARDs/biologic

Acceptability: total withdrawals · patients with rheumatoid arthritis

Tocilizumab 8 mg/kg + MTX/DMARD probably leads to lower total withdrawals compared with placebo + MTX/DMARD (moderate certainty).

1 finding from 1 review

Tocilizumab for rheumatoid arthritis 2010 · Cochrane Headline outcomes only
RR 0.61 [0.49, 0.77]
4 studies · 2064 participants
Moderate

Tocilizumab 8 mg/kg + MTX/DMARD vs placebo + DMARDs/biologic

Withdrawals due to adverse events · patients with rheumatoid arthritis

Tocilizumab 8 mg/kg + MTX/DMARD showed no clear difference in withdrawals due to Adverse events compared with placebo + MTX/DMARD (high certainty).

1 finding from 1 review

Tocilizumab for rheumatoid arthritis 2010 · Cochrane Headline outcomes only
RR 1.43 [0.95, 2.12]
4 studies · 2064 participants
High

Tocilizumab 8 mg/kg + MTX/DMARD vs placebo + DMARDs/biologic

Radiographic progression · patients with rheumatoid arthritis

1 finding from 1 review

Tocilizumab for rheumatoid arthritis 2010 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 4 participants
GRADE not reported