Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

86 questions · 99 findings · 4 reviews · Oral Health

No studies found 13 · 13.1%GRADE not reported 31 · 31.3%Very low 52 · 52.5%Low 3 · 3%Moderate 0 · 0%High 0 · 0%

Tetracycline + SRP vs SRP

Probing pocket depth · Adults with aggressive periodontitis

The review found no eligible studies for this question.

2 findings from 1 review

Tetracycline + SRP vs SRP

Clinical attachment level (CAL) · Adults with aggressive periodontitis

Tetracycline + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.

3 findings from 1 review

Tetracycline + SRP vs SRP

Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis

The review found no eligible studies for this question.

2 findings from 1 review

Tetracycline suspension (250 mg, held in mouth 2 minutes then swallowed, four times daily for 5 days) vs placebo

Adjusted maximum ulcer size and adjusted maximum pain · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Tetracycline suspension (250 mg, held in mouth 2 minutes then swallowed, four times daily for 5 days) vs placebo

Average number of new lesions per week · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Tetracycline suspension (250 mg, held in mouth 2 minutes then… showed no clear difference in average number of new lesions per week compared with placebo; GRADE not reported.

1 finding from 1 review

Autofluorescence-guided bone surgery vs Tetracycline fluorescence-guided bone surgery

Healing of MRONJ (mucosal integrity) · People with MRONJ referred for surgical treatment

It is very uncertain whether autofluorescence-guided bone surgery changes healing of MRONJ (mucosal integrity) compared with tetracycline fluorescence-guided bone surgery (very low certainty).

1 finding from 1 review

Amoxicillin + clavulanate + SRP vs Tetracycline + SRP

Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis

Amoxicillin + clavulanate + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with tetracycline + SRP; GRADE not reported.

1 finding from 1 review

6% HP strip vs 10% CP gel in tray

Tooth whitening - assessed by the dentist · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

It is very uncertain whether 6% HP strip changes tooth whitening - assessed by the dentist compared with 10% CP gel in tray (very low certainty).

2 findings from 1 review

5.3% HP strip vs 5% HP gel in tray

Patient comfort / acceptability · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

It is very uncertain whether 5.3% HP strip changes patient comfort / acceptability compared with 5% HP gel in tray (very low certainty).

1 finding from 1 review

10% CP gel in tray vs placebo

Tooth whitening - assessed by the dentist · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

It is very uncertain whether 10% CP gel in tray changes tooth whitening - assessed by the dentist compared with placebo (very low certainty).

4 findings from 1 review
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5.6% SHMP chewing gum vs placebo

Tooth whitening - assessed by the dentist · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

It is very uncertain whether 5.6% SHMP chewing gum changes tooth whitening - assessed by the dentist compared with placebo (very low certainty).

1 finding from 1 review