What do systematic reviews say?

Tacrolimus 0.1% vs Topical clobetasol propionate 0.05% ointment

Topical tacrolimus 0.1% ointment showed no clear difference in pain reduction (VAS 0-10) compared with topical clobetasol propionate 0.05% ointment; GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  MD -0.64 [-1.91, 0.63]
  1 study · 29 participants
  GRADE not reported

Tacrolimus 0.1% vs Topical clobetasol propionate 0.05% ointment

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  Table 3 (Side-effects). Radfar 2008: burning sensation with topical tacrolimus; transient burning within the first 2 weeks resulted in withdrawal of therapy in 1 participant.
  1 study · 29 participants
  GRADE not reported

Tacrolimus 0.1% vs Topical clobetasol propionate 0.05% ointment

Topical tacrolimus 0.1% ointment showed no clear difference in reduction in target/mean lesion size compared with topical clobetasol propionate 0.05% ointment; GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  MD 0.00 [-1.09, 1.10]
  1 study · 29 participants
  GRADE not reported

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

The review found no eligible studies for this question.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  No studies reported this outcome.
  0 studies
  No studies found

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

The review found no eligible studies for this question.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  None of the included studies assessed the effectiveness of treatments of genital ELP; thus, this outcome was not reported.
  0 studies
  No studies found

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

The review found no eligible studies for this question.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  No studies reported this outcome.
  0 studies
  No studies found

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

The review found no eligible studies for this question.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  No studies reported this outcome.
  0 studies
  No studies found

Topical triamcinolone acetonide vs Topical tacrolimus

Topical triamcinolone acetonide may leads to lower adverse effects compared with topical tacrolimus (low certainty).

• Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes

  3-8 weeks
  RR 0.47 [0.22, 0.99]
  2 studies · 58 participants
  Low

Topical clobetasol propionate vs Topical tacrolimus

Topical clobetasol propionate showed no clear difference in pain (mean VAS score) compared with topical tacrolimus; GRADE not reported.

• Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes

  end of treatment
  MD 0.08 [-0.33, 0.49]
  1 study · 68 participants
  GRADE not reported

Topical clobetasol propionate vs Topical tacrolimus

It is very uncertain whether topical clobetasol propionate changes clinical resolution compared with topical tacrolimus (very low certainty).

• Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes

  3-8 weeks
  RR 0.61 [0.38, 0.99]
  2 studies · 52 participants
  Very low

Topical triamcinolone acetonide vs Topical tacrolimus

It is very uncertain whether topical triamcinolone acetonide changes clinical resolution compared with topical tacrolimus (very low certainty).

• Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes

  3-8 weeks
  RR 0.86 [0.55, 1.35]
  2 studies · 60 participants
  Very low

Topical clobetasol propionate vs Topical tacrolimus

It is very uncertain whether topical clobetasol propionate changes adverse effects compared with topical tacrolimus (very low certainty).

• Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes

  3-8 weeks
  RR 0.05 [0.00, 0.83]
  2 studies · 100 participants
  Very low

Topical triamcinolone acetonide vs Topical tacrolimus

The review found no eligible studies for this question.

• Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes

  3-8 weeks
  Summary of findings 2: 'No data for this outcome' (triamcinolone vs tacrolimus, pain resolution)
  0 studies
  No studies found

Topical clobetasol propionate vs Topical tacrolimus

It is very uncertain whether topical clobetasol propionate changes pain resolution compared with topical tacrolimus (very low certainty).

• Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes

  3-8 weeks
  RR 0.45 [0.24, 0.88]
  2 studies · 100 participants
  Very low