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Evidence found and GRADE certainty

4 questions · 10 findings · 1 reviews

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Total daily fluoride intake (TDFI) and daily fluoride intake from toothpaste

Correlation between daily urinary fluoride excretion (DUFE) and fluoride intake · Children and adults with 24-h urinary fluoride monitoring (9 studies reporting both intake and urine; Table 2)

Daily urinary fluoride excretion was not correlated with total daily fluoride intake or with fluoride intake from toothpaste (R2 < 0.07), based on nine studies (ungraded).

1 finding from 1 review
  • Fluoride Intake Through Dental Care Products: A Systematic Review. 2022 All outcomes
    24-h urine collection · Multiple countries (28 studies; ~43% conducted in Brazil); community/general-population settings · High-fluoride-area data from Idowu et al. [46,47] excluded
    R2 (coefficient of determination) <0.07
    9 studies
    GRADE not reported

Fluoride-containing dental care products (mainly fluoride toothpaste) vs Dietary fluoride sources (drinking water, beverages, food)

Contribution of dental care products to total daily fluoride intake (TDFI), by tap-water fluoride level · Children using fluoride-containing dental care products (majority of included studies)

In children in low-fluoridated tap water areas, dental care products contributed on average 39% of total fluoride exposure (ungraded).

5 findings from 1 review
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Fluoride-containing dental care products (mainly fluoride toothpaste) vs Dietary fluoride sources (drinking water, beverages, food)

Contribution of dental care products to total daily fluoride intake (TDFI), by tap-water fluoride level · Adults using fluoride-containing dental care products (two included studies [28,47]; aged 20-35)

In adults in poor-fluoridated tap water areas, dental care products contributed on average 12% of total fluoride exposure (ungraded; 1-2 studies).

3 findings from 1 review

Fluoride-containing dental care products (mainly fluoride toothpaste; one study also included fluoride varnish) vs Dietary fluoride sources (drinking water, beverages, food)

Contribution of dental care products to total daily fluoride intake (TDFI) · Humans using fluoride-containing dental care products; 28 included studies, mostly young children, only two studies in adults (aged…

Fluoride-containing dental care products (mainly toothpaste) contributed on average 38% (SD 27%) of total daily fluoride intake, regardless of tap-water fluoride level or age (ungraded; descriptive synthesis, no meta-analysis).

1 finding from 1 review