Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

14 questions · 14 findings · 2 reviews · Pregnancy and Childbirth

No studies found 1 · 7.1%GRADE not reported 0 · 0%Very low 7 · 50%Low 2 · 14.3%Moderate 2 · 14.3%High 2 · 14.3%

Nitrofurantoin and close surveillance vs close surveillance alone

Recurrent pyelonephritis · pregnant women with a history of one or more UTI before or during pregnancy

It is very uncertain whether nitrofurantoin and close surveillance changes recurrent pyelonephritis compared with close surveillance alone (very low certainty).

1 finding from 1 review

Nitrofurantoin and close surveillance vs close surveillance alone

Recurrent UTI (cystitis) · pregnant women with a history of one or more UTI before or during pregnancy

It is very uncertain whether nitrofurantoin and close surveillance changes recurrent UTI (cystitis) compared with close surveillance alone (very low certainty).

1 finding from 1 review

Nitrofurantoin and close surveillance vs close surveillance alone

Preterm birth · pregnant women with a history of one or more UTI before or during pregnancy

It is very uncertain whether nitrofurantoin and close surveillance changes preterm birth (< 37 weeks) compared with close surveillance alone (very low certainty).

1 finding from 1 review

Nitrofurantoin and close surveillance vs close surveillance alone

Birthweight < 2500 (g) · pregnant women with a history of one or more UTI before or during pregnancy

It is very uncertain whether nitrofurantoin and close surveillance changes birthweight < 2500 (g) compared with close surveillance alone (very low certainty).

1 finding from 1 review

Nitrofurantoin and close surveillance vs close surveillance alone

Apgar score less than 7 at 5 minutes · pregnant women with a history of one or more UTI before or during pregnancy

It is very uncertain whether nitrofurantoin and close surveillance changes five‐minute Apgar score < seven compared with close surveillance alone (very low certainty).

1 finding from 1 review

Nitrofurantoin and close surveillance vs close surveillance alone

Miscarriage · pregnant women with a history of one or more UTI before or during pregnancy

It is very uncertain whether nitrofurantoin and close surveillance changes miscarriages compared with close surveillance alone (very low certainty).

1 finding from 1 review

Fetal growth (biometry) + umbilical artery Doppler vs fetal growth

Any perinatal death after randomisation · women with twin pregnancies were randomised from 25 weeks

Fetal growth (biometry) + umbilical artery Doppler showed no clear difference in perinatal mortality (after randomisation) compared with fetal growth (low certainty).

1 finding from 1 review

Fetal growth (biometry) + umbilical artery Doppler vs fetal growth

Gestational age at birth (weeks) · women with twin pregnancies were randomised from 25 weeks

Fetal growth (biometry) + umbilical artery Doppler showed no clear difference in gestational age at birth (weeks) compared with fetal growth (moderate certainty).

1 finding from 1 review

Fetal growth (biometry) + umbilical artery Doppler vs fetal growth

Number of antenatal hospital admissions · women with twin pregnancies were randomised from 25 weeks

Fetal growth (biometry) + umbilical artery Doppler showed no clear difference in antenatal admission to hospital compared with fetal growth (high certainty).

1 finding from 1 review