Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

174 questions · 177 findings · 15 reviews · Gut

No studies found 30 · 16.9%GRADE not reported 4 · 2.3%Very low 72 · 40.7%Low 45 · 25.4%Moderate 24 · 13.6%High 2 · 1.1%

Non‐surgical vs surgical treatment of oesophageal cancer (primary outcomes)

Long‐term recurrence (> 5 years) · patients with oesophageal cancer

It is very uncertain whether non‐surgical changes long‐term recurrence (binary outcome) Local recurrence, surgical… compared with surgical treatment of oesophageal cancer (secondary outcomes) (very low certainty).

1 finding from 1 review

Non‐surgical vs surgical treatment of oesophageal cancer (primary outcomes)

Long‐term recurrence (maximal · patients with oesophageal cancer

Non‐surgical showed no clear difference in long‐term recurrence (time‐to‐event outcome) Local recurrence,… compared with surgical treatment of oesophageal cancer (secondary outcomes) (low certainty).

1 finding from 1 review

Non‐surgical vs surgical treatment of oesophageal cancer (primary outcomes)

Short‐term mortality All‐cause mortality either in‐hospital or within 3 months · patients with oesophageal cancer

It is very uncertain whether non‐surgical changes short‐term mortality All‐cause mortality either in‐hospital or… compared with surgical treatment of oesophageal cancer (primary outcomes) (very low certainty).

1 finding from 1 review

Non‐surgical vs surgical treatment of oesophageal cancer (primary outcomes)

Proportion with any adverse event within 3 months Any adverse event within 3 months of any severity · patients with oesophageal cancer

It is very uncertain whether non‐surgical changes proportion with any adverse event within 3 months Any adverse event… compared with surgical treatment of oesophageal cancer (secondary outcomes) (very low certainty).

1 finding from 1 review

Non‐surgical vs surgical treatment of oesophageal cancer (primary outcomes)

Long‐term mortality (binary outcome) All‐cause mortality for the duration of · patients with oesophageal cancer

Non‐surgical showed no clear difference in long‐term mortality (binary outcome) All‐cause mortality for the… compared with surgical treatment of oesophageal cancer (primary outcomes) (low certainty).

2 findings from 1 review

Non‐surgical vs surgical treatment of oesophageal cancer (primary outcomes)

Long‐term mortality (time‐to‐event outcome): chemoradiotherapy versus surgery All‐cause mortality for the duration of · patients with oesophageal cancer

Non‐surgical showed no clear difference in long‐term mortality (time‐to‐event outcome): chemoradiotherapy… compared with surgical treatment of oesophageal cancer (primary outcomes) (low certainty).

2 findings from 1 review

Non‐surgical vs surgical treatment of oesophageal cancer (primary outcomes)

Long‐term mortality (time‐to‐event outcome): radiotherapy versus surgery All‐cause mortality for the duration of · patients with oesophageal cancer

It is very uncertain whether non‐surgical changes long‐term mortality (time‐to‐event outcome): radiotherapy versus… compared with surgical treatment of oesophageal cancer (primary outcomes) (very low certainty).

1 finding from 1 review

Non‐surgical vs surgical treatment of oesophageal cancer (primary outcomes)

Proportion of participants with 1 or more serious adverse events according to International Conference on Harmonisation Good Clinical Practice (ICH‐GCP) · patients with oesophageal cancer

It is very uncertain whether non‐surgical changes proportion with a serious adverse event within 3 months Serious… compared with surgical treatment of oesophageal cancer (primary outcomes) (very low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Surgical relapse · people with surgically‐induced remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes surgical relapse compared with 5‐aminosalicylic acid (very low certainty).

1 finding from 1 review

Duct‐to‐mucosa pancreaticojejunostomy using the modified Blumgart technique vs duct‐to‐mucosa pancreaticojejunostomy using the traditional interrupted technique

Rate of surgical reintervention · adults undergoing open pancreaticoduodenectomy

It is very uncertain whether duct‐to‐mucosa pancreaticojejunostomy using the modified Blumgart… changes rate of surgical reintervention compared with duct‐to‐mucosa pancreaticojejunostomy using the traditional… (very low certainty).

1 finding from 1 review

Duct‐to‐mucosa pancreaticojejunostomy using the modified Blumgart technique vs duct‐to‐mucosa pancreaticojejunostomy using the traditional interrupted technique

Overall rate of surgical complications · adults undergoing open pancreaticoduodenectomy

It is very uncertain whether duct‐to‐mucosa pancreaticojejunostomy using the modified Blumgart… changes overall rate of surgical complications compared with duct‐to‐mucosa pancreaticojejunostomy using the traditional… (very low certainty).

1 finding from 1 review