Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

35 questions · 35 findings · 1 reviews · Schizophrenia · Headline outcomes only

No studies found 0 · 0%GRADE not reported 14 · 40%Very low 21 · 60%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Group B antipsychotic drugs: olanzapine + supportive intervention vs placebo or supportive treatment

Prodromal symptoms: transition to psychosis Endpoint data (events) · people in the prodromal stage of psychosis

It is very uncertain whether group B antipsychotic drugs: olanzapine + supportive intervention changes prodromal symptoms: transition to psychosis Endpoint data, (events)… compared with placebo + supportive intervention (very low certainty).

1 finding from 1 review

Group B antipsychotic drugs: olanzapine + supportive intervention vs placebo or supportive treatment

Satisfaction and acceptability of treatment (medium term) ‐ leaving the study early · people in the prodromal stage of psychosis

It is very uncertain whether group B antipsychotic drugs: olanzapine + supportive intervention changes satisfaction with treatment: leaving the study early Endpoint data… compared with placebo + supportive intervention (very low certainty).

1 finding from 1 review

Group C cognitive behavioural therapy: cognitive behavioural therapy + supportive intervention vs non‐directive reflective listening + supportive intervention

Prodromal symptoms: transition to psychosis Endpoint data (events) · people in the prodromal stage of psychosis

It is very uncertain whether group C cognitive behavioural therapy: cognitive behavioural therapy… changes prodromal symptoms: transition to psychosis Endpoint data (events) compared with non‐directive reflective listening + supportive intervention (very low certainty).

1 finding from 1 review

Group C cognitive behavioural therapy: cognitive behavioural therapy + supportive intervention vs non‐directive reflective listening + supportive intervention

Satisfaction with treatment: leaving the study early Endpoint data (events) · people in the prodromal stage of psychosis

It is very uncertain whether group C cognitive behavioural therapy: cognitive behavioural therapy… changes satisfaction with treatment: leaving the study early Endpoint data… compared with non‐directive reflective listening + supportive intervention (very low certainty).

1 finding from 1 review

Group B cognitive behavioural therapy: cognitive behavioural therapy + supportive therapy vs supportive therapy

Prodromal symptoms: transition to psychosis Endpoint data (events) · people in the prodromal stage of psychosis

It is very uncertain whether group B cognitive behavioural therapy: cognitive behavioural therapy… changes prodromal symptoms: transition to psychosis Long‐term (events) compared with supportive therapy (very low certainty).

1 finding from 1 review