Intervention not reported
Folate concentration Serum folate levels, measured between 6 and 12 months after entry to the study · 117 children with homozygous sickle cell (SS) disease
1 finding from 1 review
Intervention not reported
Haemoglobin concentration Haematological analyses were performed in the 100/115 (87%) children in whom baseline (within 2 months of entry to study) and 1 year (between 10 and 14 months after entry) · 117 children with homozygous sickle cell (SS) disease
1 finding from 1 review
Intervention not reported
Outcomes1 · 117 children with homozygous sickle cell (SS) disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Adverse events ‐ acute splenic sequestration Clinical events experienced by children during the 1 year period commencing at entry to the trial · 117 children with homozygous sickle cell (SS) disease
The intervention showed no clear difference in adverse events ‐ acute splenic sequestration Clinical events… (low certainty).
1 finding from 1 review
Intervention not reported
Adverse events ‐ painful episodes Clinical events experienced by children during the 1 year period commencing at entry to the trial · 117 children with homozygous sickle cell (SS) disease
The intervention showed no clear difference in adverse events ‐ painful episodes Clinical events experienced by… (low certainty).
1 finding from 1 review
Intervention not reported
Adverse events ‐ minor Infections Clinical events experienced by children during the 1 year period commencing at entry to the trial · 117 children with homozygous sickle cell (SS) disease
The intervention showed no clear difference in adverse events ‐ minor Infections Clinical events experienced by… (low certainty).
1 finding from 1 review
Intervention not reported
Adverse events ‐ major infections Clinical events experienced by children during the 1 year period commencing at entry to the trial · 117 children with homozygous sickle cell (SS) disease
The intervention showed no clear difference in adverse events ‐ major infections Clinical events experienced by… (low certainty).
1 finding from 1 review
Intervention not reported
Adverse events ‐ dactylitis Clinical events experienced by children during the 1 year period commencing at entry to the trial · 117 children with homozygous sickle cell (SS) disease
The intervention showed no clear difference in adverse events ‐ dactylitis Clinical events experienced by children… (low certainty).
1 finding from 1 review