Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews

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No studies found 1 · 16.7%GRADE not reported 0 · 0%Very low 0 · 0%Low 5 · 83.3%Moderate 0 · 0%High 0 · 0%

Summary of findings: Trihexyphenidyl vs placebo

Change in dystonia from baseline Measured by: BADS (eight body regions assessed for dystonia on a five‐point scale (0 = none to 4 = severe), minimum score 0 to maximum score 32; higher score = greater severity of dystonia) · children with dystonic cerebral palsy

1 finding from 1 review

Trihexyphenidyl for dystonia in cerebral palsy 2018 · Cochrane Headline outcomes only
no estimate extracted
16 participants
Low

Summary of findings: Trihexyphenidyl vs placebo

Adverse effectsb (mood disturbance, irritability, behavioural change, constipation) Measured by: counts of number and type · children with dystonic cerebral palsy

Summary of findings: Trihexyphenidyl may leads to higher adverse effectsb (mood disturbance, irritability, behavioural… compared with placebo (low certainty).

1 finding from 1 review

Trihexyphenidyl for dystonia in cerebral palsy 2018 · Cochrane Headline outcomes only
RR 2.54 [1.38, 4.67]
16 participants
Low

Summary of findings: Trihexyphenidyl vs placebo

Participation in activities of daily living:individual goal setting Measured by: GAS (up to 5 functional goals scored on a 5‐point scale (−2 = much less than expected to +2 = much more than expected); higher score = better than expected outcome) · children with dystonic cerebral palsy

1 finding from 1 review

Trihexyphenidyl for dystonia in cerebral palsy 2018 · Cochrane Headline outcomes only
no estimate extracted
16 participants
Low

Summary of findings: Trihexyphenidyl vs placebo

Participation in activities of daily living:satisfaction with individual goals Measured by: satisfaction subscale of the COPM (satisfaction with performance in up to 5 problem areas scored on a 10‐point scale (1 = not satisfied at all to 10 = extr... · children with dystonic cerebral palsy

1 finding from 1 review

Trihexyphenidyl for dystonia in cerebral palsy 2018 · Cochrane Headline outcomes only
no estimate extracted
16 participants
Low

Summary of findings: Trihexyphenidyl vs placebo

Participation in activities of daily living:performance of individual goals Measured by: performance subscale of the COPM (up to five problem areas scored on a 10‐point scale (1 = not able to do to 10 = able to do extremely well; higher score = be... · children with dystonic cerebral palsy

1 finding from 1 review

Trihexyphenidyl for dystonia in cerebral palsy 2018 · Cochrane Headline outcomes only
no estimate extracted
16 participants
Low

Summary of findings: Trihexyphenidyl vs placebo

Quality of life · children with dystonic cerebral palsy

The review found no eligible studies for this question.

1 finding from 1 review

Trihexyphenidyl for dystonia in cerebral palsy 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found