Summary of findings: levodopa vs placebo
Severity of symptoms (rating from 0 = not present to 10 = severe) · patients with restless legs syndrome
1 finding from 1 review
- no estimate extracted2 studies · 48 participantsModerate
Findings
What do systematic reviews say?
52 questions · 52 findings · 3 reviews · Movement Disorders
No studies found 6 · 11.5%GRADE not reported 0 · 0%Very low 13 · 25%Low 9 · 17.3%Moderate 20 · 38.5%High 4 · 7.7%
Summary of findings: levodopa vs other dopamine agonists
Total sleep time, next night; · patients with restless legs syndrome
1 finding from 1 review
- no estimate extracted1 study · 11 participantsVery low
Summary of findings: levodopa vs other dopamine agonists
Adverse effects (drop‐outs due to adverse effects4) · patients with restless legs syndrome
Summary of findings: levodopa probably leads to lower number of drop outs due to adverse events compared with other dopamine agonists (moderate certainty).
1 finding from 1 review
- OR 0.593 studies · 504 participantsModerate
Summary of findings: levodopa vs other dopamine agonists
Clinical Global Impressions ‐ Improvement of condition (CGI‐I) Rating of 1 = very much improved to 7 = very much worse · patients with restless legs syndrome
1 finding from 1 review
- no estimate extracted1 study · 344 participantsModerate
Summary of findings: levodopa vs other dopamine agonists
Quality of sleep · patients with restless legs syndrome
1 finding from 1 review
- no estimate extracted1 study · 344 participantsLow
Summary of findings: levodopa vs other dopamine agonists
QoL · patients with restless legs syndrome
1 finding from 1 review
- no estimate extracted1 study · 314 participantsModerate
Summary of findings: levodopa vs placebo
Periodic limb movements in sleep (PLMS Index) PLMS per hour of sleep (8 trials) or time in bed (7 trials) · patients with restless legs syndrome
1 finding from 1 review
- no estimate extracted5 studies · 91 participantsModerate
Summary of findings: levodopa vs placebo
Total sleep time, next night; · patients with restless legs syndrome
1 finding from 1 review
- no estimate extracted4 studies · 59 participantsLow
Summary of findings: levodopa vs placebo
Dropouts due to adverse events · patients with restless legs syndrome
Summary of findings: levodopa showed no clear difference in dropouts due to adverse events compared with placebo (moderate certainty).
1 finding from 1 review
- OR 0.73 [0.05, 11.34]6 studies · 109 participantsModerate
Summary of findings: levodopa vs placebo
Clinical Global Impressions ‐ Improvement of condition (CGI‐I) Rating of 1 = very much improved to 7 = very much worse · patients with restless legs syndrome
1 finding from 1 review
- no estimate extracted2 studies · 60 participantsModerate
Summary of findings: levodopa vs placebo
Quality of sleep · patients with restless legs syndrome
1 finding from 1 review
- no estimate extracted2 studies · 60 participantsModerate
Summary of findings: levodopa vs placebo
Quality of life VAS on life satisfaction (0 to 50 = high) · patients with restless legs syndrome
1 finding from 1 review
- no estimate extracted2 studies · 60 participantsModerate
Summary of findings: levodopa vs other dopamine agonists
IRLS · patients with restless legs syndrome
1 finding from 1 review
- no estimate extracted2 studies · 383 participantsModerate
Summary of findings: levodopa vs other dopamine agonists
Periodic limb movements per hour of time in bed · patients with restless legs syndrome
1 finding from 1 review
- no estimate extracted1 study · 39 participantsLow
Exercise vs control
Falls · people with Parkinson's disease
Summary of findings for exercise probably leads to lower rate of Falls (falls per person‐year) compared with control (moderate certainty).
1 finding from 1 review
- Rate ratio 0.74 [0.63, 0.87]12 studies · 1456 participantsModerate
Exercise vs control
Number of people who experienced one or more falls · people with Parkinson's disease
Summary of findings for exercise showed no clear difference in number of people who experienced one or more falls compared with control (moderate certainty).
1 finding from 1 review
- Risk ratio 0.9 [0.8, 1]9 studies · 932 participantsModerate
Exercise vs control
Number of people sustaining one or more fall‐related fractures · people with Parkinson's disease
It is very uncertain whether summary of findings for exercise changes number of people sustaining one or more fall‐related fractures compared with control (very low certainty).
1 finding from 1 review
- Risk ratio 0.57 [0.28, 1.17]5 studies · 989 participantsVery low
Exercise vs control
Quality of life immediately after the intervention · people with Parkinson's disease
1 finding from 1 review
- no estimate extracted5 studies · 951 participantsLow
Exercise vs control
Adverse events · people with Parkinson's disease
1 finding from 1 review
- no estimate extracted8 studies · 1242 participantsVery low
Exercise vs control
Economic outcomes · people with Parkinson's disease
1 finding from 1 review
- no estimate extracted4 studies · 923 participantsVery low