Findings

What do systematic reviews say?

8 questions · 8 findings · 3 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

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No studies found 1 · 12.5%GRADE not reported 0 · 0%Very low 1 · 12.5%Low 0 · 0%Moderate 4 · 50%High 2 · 25%

Antibiotics vs placebo or no intervention

Bacteraemia · patients with afebrile neutropenia induced by chemotherapy

Summary of findings: antibiotics leads to lower bacteraemia compared with placebo or no intervention (high certainty).

1 finding from 1 review

Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy 2012 · Cochrane Headline outcomes only
RR 0.5
53 studies · 6390 participants
High

Summary of findings: quinolone prophylaxis vs TMP‐SMZ prophylaxis

Bacteraemia · cancer patients with afebrile neutropenia following chemotherapy

Summary of findings: quinolone prophylaxis probably leads to lower bacteraemia compared with TMP‐SMZ prophylaxis (moderate certainty).

1 finding from 1 review

Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy 2012 · Cochrane Headline outcomes only
RR 0.89
10 studies · 931 participants
Moderate

Intervention diet vs usual on‐treatment diet

Lactose‐restricted diet · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Lifestyle interventions vs placebo or usual care

Quality of life: FACT‐G (12 months) · weight reduction in obesity to improve survival in women with endometrial cancer

1 finding from 1 review

Interventions for weight reduction in obesity to improve survival in women with endometrial cancer 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 89 participants
Very low

Antibiotics vs placebo or no intervention

All cause mortality · patients with afebrile neutropenia induced by chemotherapy

Summary of findings: antibiotics leads to lower all cause mortality compared with placebo or no intervention (high certainty).

1 finding from 1 review

Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy 2012 · Cochrane Headline outcomes only
RR 0.66
46 studies · 5635 participants
High

Antibiotics vs placebo or no intervention

Febrile patients and episodes · patients with afebrile neutropenia induced by chemotherapy

Summary of findings: antibiotics probably leads to lower febrile patients and episodes compared with placebo or no intervention (moderate certainty).

1 finding from 1 review

Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy 2012 · Cochrane Headline outcomes only
RR 0.8
54 studies · 6658 participants
Moderate

Summary of findings: quinolone prophylaxis vs TMP‐SMZ prophylaxis

All cause‐mortality · cancer patients with afebrile neutropenia following chemotherapy

Summary of findings: quinolone prophylaxis probably leads to higher all cause‐mortality compared with TMP‐SMZ prophylaxis (moderate certainty).

1 finding from 1 review

Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy 2012 · Cochrane Headline outcomes only
RR 1.07
10 studies · 917 participants
Moderate

Summary of findings: quinolone prophylaxis vs TMP‐SMZ prophylaxis

Febrile patients and episodes · cancer patients with afebrile neutropenia following chemotherapy

Summary of findings: quinolone prophylaxis probably leads to lower febrile patients and episodes compared with TMP‐SMZ prophylaxis (moderate certainty).

1 finding from 1 review

Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy 2012 · Cochrane Headline outcomes only
RR 0.92
10 studies · 931 participants
Moderate