Findings

What do systematic reviews say?

16 questions · 16 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 9 · 56.3%Low 4 · 25%Moderate 3 · 18.8%High 0 · 0%

Standard‐dose adrenaline (SDA) vs SDA plus vasopressin

Survival to hospital discharge · people suffering cardiac arrest

It is very uncertain whether standard‐dose adrenaline (SDA) changes survival to hospital discharge compared with SDA plus vasopressin (very low certainty).

1 finding from 1 review

Adrenaline and vasopressin for cardiac arrest 2019 · Cochrane Headline outcomes only
RR 0.76 [0.47, 1.22]
3 studies · 3242 participants
Very low

Standard‐dose adrenaline (SDA) vs SDA plus vasopressin

Survival to hospital admission · people suffering cardiac arrest

Standard‐dose adrenaline (SDA) showed no clear difference in survival to hospital admission compared with SDA plus vasopressin (low certainty).

1 finding from 1 review

Adrenaline and vasopressin for cardiac arrest 2019 · Cochrane Headline outcomes only
RR 0.95 [0.83, 1.08]
3 studies · 3249 participants
Low

Standard‐dose adrenaline (SDA) vs SDA plus vasopressin

Favourable neurological outcomes · people suffering cardiac arrest

It is very uncertain whether standard‐dose adrenaline (SDA) changes favourable neurological outcomes compared with SDA plus vasopressin (very low certainty).

1 finding from 1 review

Adrenaline and vasopressin for cardiac arrest 2019 · Cochrane Headline outcomes only
RR 0.65 [0.33, 1.31]
1 study · 2887 participants
Very low

Standard‐dose adrenaline (SDA) vs SDA plus vasopressin

Return of spontaneous circulation · people suffering cardiac arrest

Standard‐dose adrenaline (SDA) showed no clear difference in return of spontaneous circulation compared with SDA plus vasopressin (low certainty).

1 finding from 1 review

Adrenaline and vasopressin for cardiac arrest 2019 · Cochrane Headline outcomes only
RR 0.97 [0.87, 1.08]
3 studies · 3249 participants
Low

Standard‐dose adrenaline (SDA) vs high‐dose adrenaline (HDA)

Survival to hospital discharge · people suffering cardiac arrest

It is very uncertain whether standard‐dose adrenaline (SDA) changes survival to hospital discharge compared with high‐dose adrenaline (HDA) (very low certainty).

1 finding from 1 review

Adrenaline and vasopressin for cardiac arrest 2019 · Cochrane Headline outcomes only
RR 1.1 [0.75, 1.62]
10 studies · 6274 participants
Very low

Standard‐dose adrenaline (SDA) vs high‐dose adrenaline (HDA)

Survival to hospital admission · people suffering cardiac arrest

It is very uncertain whether standard‐dose adrenaline (SDA) changes survival to hospital admission compared with high‐dose adrenaline (HDA) (very low certainty).

1 finding from 1 review

Adrenaline and vasopressin for cardiac arrest 2019 · Cochrane Headline outcomes only
RR 1.13 [1.03, 1.24]
5 studies · 5764 participants
Very low

Standard‐dose adrenaline (SDA) vs high‐dose adrenaline (HDA)

Favourable neurological outcomes · people suffering cardiac arrest

It is very uncertain whether standard‐dose adrenaline (SDA) changes favourable neurological outcomes compared with high‐dose adrenaline (HDA) (very low certainty).

1 finding from 1 review

Adrenaline and vasopressin for cardiac arrest 2019 · Cochrane Headline outcomes only
RR 0.91 [0.65, 1.26]
4 studies · 5803 participants
Very low

Standard‐dose adrenaline (SDA) vs high‐dose adrenaline (HDA)

Return of spontaneous circulation · people suffering cardiac arrest

It is very uncertain whether standard‐dose adrenaline (SDA) changes return of spontaneous circulation compared with high‐dose adrenaline (HDA) (very low certainty).

1 finding from 1 review

Adrenaline and vasopressin for cardiac arrest 2019 · Cochrane Headline outcomes only
RR 1.15 [1.02, 1.29]
13 studies · 7014 participants
Very low

Standard‐dose adrenaline (SDA) vs placebo

Survival to hospital discharge · people suffering cardiac arrest

Standard‐dose adrenaline (SDA) probably leads to higher survival to hospital discharge compared with placebo (moderate certainty).

1 finding from 1 review

Adrenaline and vasopressin for cardiac arrest 2019 · Cochrane Headline outcomes only
RR 1.44 [1.11, 1.86]
2 studies · 8538 participants
Moderate

Standard‐dose adrenaline (SDA) vs vasopressin

Survival to hospital admission · people suffering cardiac arrest

Standard‐dose adrenaline (SDA) may leads to higher survival to hospital admission compared with vasopressin (low certainty).

1 finding from 1 review

Adrenaline and vasopressin for cardiac arrest 2019 · Cochrane Headline outcomes only
RR 1.27 [1.04, 1.54]
3 studies · 1953 participants
Low

Standard‐dose adrenaline (SDA) vs vasopressin

Favourable neurological outcomes · people suffering cardiac arrest

It is very uncertain whether standard‐dose adrenaline (SDA) changes favourable neurological outcomes compared with vasopressin (very low certainty).

1 finding from 1 review

Adrenaline and vasopressin for cardiac arrest 2019 · Cochrane Headline outcomes only
RR 0.82 [0.54, 1.25]
4 studies · 2406 participants
Very low

Standard‐dose adrenaline (SDA) vs vasopressin

Return of spontaneous circulation · people suffering cardiac arrest

It is very uncertain whether standard‐dose adrenaline (SDA) changes return of spontaneous circulation compared with vasopressin (very low certainty).

1 finding from 1 review

Adrenaline and vasopressin for cardiac arrest 2019 · Cochrane Headline outcomes only
RR 1.1 [0.9, 1.33]
6 studies · 2531 participants
Very low

Standard‐dose adrenaline (SDA) vs placebo

Survival to hospital admission · people suffering cardiac arrest

Standard‐dose adrenaline (SDA) probably leads to higher survival to hospital admission compared with placebo (moderate certainty).

1 finding from 1 review

Adrenaline and vasopressin for cardiac arrest 2019 · Cochrane Headline outcomes only
RR 2.51 [1.67, 3.76]
2 studies · 8489 participants
Moderate

Standard‐dose adrenaline (SDA) vs placebo

Favourable neurological outcomes · people suffering cardiac arrest

Standard‐dose adrenaline (SDA) showed no clear difference in favourable neurological outcomes compared with placebo (low certainty).

1 finding from 1 review

Adrenaline and vasopressin for cardiac arrest 2019 · Cochrane Headline outcomes only
RR 1.21 [0.9, 1.62]
2 studies · 8535 participants
Low

Standard‐dose adrenaline (SDA) vs placebo

Return of spontaneous circulation · people suffering cardiac arrest

Standard‐dose adrenaline (SDA) probably leads to higher return of spontaneous circulation compared with placebo (moderate certainty).

1 finding from 1 review

Adrenaline and vasopressin for cardiac arrest 2019 · Cochrane Headline outcomes only
RR 2.86 [2.21, 3.71]
3 studies · 8663 participants
Moderate

Standard‐dose adrenaline (SDA) vs vasopressin

Survival to hospital discharge · people suffering cardiac arrest

It is very uncertain whether standard‐dose adrenaline (SDA) changes survival to hospital discharge compared with vasopressin (very low certainty).

1 finding from 1 review

Adrenaline and vasopressin for cardiac arrest 2019 · Cochrane Headline outcomes only
RR 1.25
6 studies · 2511 participants
Very low