Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

93 questions · 93 findings · 16 reviews · Oral Health

No studies found 5 · 5.4%GRADE not reported 65 · 69.9%Very low 13 · 14%Low 8 · 8.6%Moderate 2 · 2.2%High 0 · 0%

One soft tissue correction/augmentation technique vs A different soft tissue correction/augmentation technique

Outcome not reported · Patients receiving dental implants

The review found no eligible studies for this question.

1 finding from 1 review

Subepithelial connective tissue graft (palate) at implant placement vs No augmentation

Soft tissue thickness change · Partially edentulous patients receiving posterior mandibular implants

Subepithelial connective tissue graft (palate) at implant placement led to lower soft tissue thickness change compared with no augmentation; GRADE not reported.

1 finding from 1 review

Passive maxillary/obturating plate (worn until surgical closure of soft palate) vs No plate

Weight (kg) · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…

Passive maxillary/obturating plate (worn until surgical closure of… showed no clear difference in weight (kg) compared with no plate; GRADE not reported.

1 finding from 1 review

Passive maxillary/obturating plate (worn until surgical closure of soft palate) vs No plate

Head circumference (mm) · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…

Passive maxillary/obturating plate (worn until surgical closure of… showed no clear difference in head circumference (cm) compared with no plate; GRADE not reported.

1 finding from 1 review

Passive maxillary/obturating plate (worn until surgical closure of soft palate) vs No plate

Length (cm) · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…

Passive maxillary/obturating plate (worn until surgical closure of… showed no clear difference in length (cm) compared with no plate; GRADE not reported.

1 finding from 1 review

Concentrated growth factor (CGF) and primary wound closure vs primary closure

Healing of MRONJ (soft tissue healing) · Women with osteoporosis and established MRONJ

It is very uncertain whether concentrated growth factor (CGF) and primary wound closure changes healing of MRONJ (soft tissue healing) compared with primary wound closure only (very low certainty).

1 finding from 1 review

2% mepivacaine, 1:20,000 levonordefrin vs 2% lidocaine, 1:100,000 epinephrine

Duration of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 2% mepivacaine, 1:20,000 levonordefrin changes duration of anaesthesia (soft tissue, simulated) compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

3% mepivacaine plain vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia (soft tissue, self-reported; 100% success in all studies) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
1 finding from 1 review
  • '100% success' (lidocaine 1:100,000 vs 3% mepivacaine plain): infraorbital block - Berberich 2009 40/40 vs 40/40; IANB - Cohen 1993 27/27 vs 34/34, McLean 1993 30/30 vs 30/30. Both 100% successful.
    3 studies · 121 participants
    GRADE not reported

2% mepivacaine, 1:100,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia (soft tissue, self-reported; 100% success in all studies) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
1 finding from 1 review
  • 'Other comparisons with 100% success': IANB - Allegretti 2016 22/22 vs 22/22; Visconti 2016 21/21 vs 21/21. Both formulations 100% successful; no meta-analysis (no difference).
    2 studies · 43 participants
    GRADE not reported

4% prilocaine plain vs 2% lidocaine, 1:100,000 epinephrine

Duration of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 4% prilocaine plain changes duration of anaesthesia (soft tissue, simulated) compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

4% articaine, 1:100,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Speed of onset of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 4% articaine, 1:100,000 epinephrine changes speed of onset of anaesthesia (soft tissue, simulated) compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

4% prilocaine, 1:200,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Speed of onset of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

4% prilocaine, 1:200,000 epinephrine showed no clear difference in speed of onset of anaesthesia (soft tissue, simulated) compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).

1 finding from 1 review

4% prilocaine plain vs 2% lidocaine, 1:100,000 epinephrine

Speed of onset of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

4% prilocaine plain showed no clear difference in speed of onset of anaesthesia (soft tissue, simulated) compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).

1 finding from 1 review

4% articaine, 1:100,000 epinephrine vs 2% mepivacaine, 1:100,000 epinephrine

Success of local anaesthesia (soft tissue, self-reported; 100% success in all studies) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 4% articaine, 1:100,000 epinephrine changes success of local anaesthesia (soft tissue, self-reported) compared with 2% mepivacaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

2% lidocaine, 1:50,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia (soft tissue, self-reported; 100% success in all studies) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
1 finding from 1 review
  • '100% success' (lidocaine 1:100,000 vs 1:50,000): infraorbital block - Berberich 2009 40/40 vs 40/40; mandibular BI - Dagher 1997 30/30, Yonchak 2001 40/40; IANB - Yared 1997 30/30, Wali 2010 30/30. Both 100% successful.
    5 studies · 170 participants
    GRADE not reported

4% prilocaine, 1:200,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Duration of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 4% prilocaine, 1:200,000 epinephrine changes duration of anaesthesia (soft tissue, simulated) compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

0.5% bupivacaine, 1:200,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Speed of onset of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 0.5% bupivacaine, 1:200,000 epinephrine changes speed of onset of anaesthesia (soft tissue, simulated) compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

4% articaine, 1:100,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia (soft tissue, self-reported; 100% success in all studies) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

4% articaine, 1:100,000 epinephrine showed no clear difference in success of local anaesthesia (soft tissue, self-reported) compared with 2% lidocaine, 1:100,000 epinephrine (moderate certainty).

1 finding from 1 review

4% prilocaine, 1:200,000 epinephrine vs 4% prilocaine plain

Duration of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

4% prilocaine, 1:200,000 epinephrine may leads to higher duration of anaesthesia (soft tissue, simulated) compared with 4% prilocaine plain (low certainty).

1 finding from 1 review

0.5% bupivacaine, 1:200,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia, absence of pain (clinical testing of healthy pulps, hard and soft tissues) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

0.5% bupivacaine, 1:200,000 epinephrine showed no clear difference in success of local anaesthesia, absence of pain (clinical testing of… compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).

1 finding from 1 review