Findings

What do systematic reviews say?

8 questions · 8 findings · 2 reviews · Neonatal · Headline outcomes only

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No studies found 3 · 37.5%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 37.5%Moderate 2 · 25%High 0 · 0%

Slow vs faster rates of enteral feed advancement

Necrotising enterocolitis · very preterm or very low birth weight infants

Slow showed no clear difference in necrotising enterocolitis before hospital discharge compared with faster rates of enteral feed advancement (moderate certainty).

1 finding from 1 review

Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants 2021 · Cochrane Headline outcomes only
RR 1.06 [0.83, 1.37]
14 studies · 4026 participants
Moderate

Slow vs faster rates of enteral feed advancement

Mortality before hospital discharge · very preterm or very low birth weight infants

Slow showed no clear difference in mortality before hospital discharge compared with faster rates of enteral feed advancement (moderate certainty).

1 finding from 1 review

Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants 2021 · Cochrane Headline outcomes only
RR 1.13 [0.91, 1.39]
13 studies · 3860 participants
Moderate

Slow vs faster rates of enteral feed advancement

Feed intolerance · very preterm or very low birth weight infants

Slow may leads to higher feed intolerance before hospital discharge compared with faster rates of enteral feed advancement (low certainty).

1 finding from 1 review

Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants 2021 · Cochrane Headline outcomes only
RR 1.18
9 studies · 719 participants
Low

Slow vs faster rates of enteral feed advancement

Invasive infection (before hospital discharge) · very preterm or very low birth weight infants

Slow showed no clear difference in invasive infection before hospital discharge compared with faster rates of enteral feed advancement (low certainty).

1 finding from 1 review

Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants 2021 · Cochrane Headline outcomes only
RR 1.14 [0.99, 1.31]
11 studies · 3583 participants
Low

CLACfast vs CLACslow

All‐cause in‐hospital mortality by 36 weeks' postmenstrual ageUnit: number of infants with event · preterm infants with respiratory dysfunction

The review found no eligible studies for this question.

1 finding from 1 review

Automated oxygen delivery for preterm infants with respiratory dysfunction 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CLACfast vs CLACslow

Severe ROPUnit: number of infants with event · preterm infants with respiratory dysfunction

The review found no eligible studies for this question.

1 finding from 1 review

Automated oxygen delivery for preterm infants with respiratory dysfunction 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CLACfast vs CLACslow

Neurodevelopmental outcomes · preterm infants with respiratory dysfunction

The review found no eligible studies for this question.

1 finding from 1 review

Automated oxygen delivery for preterm infants with respiratory dysfunction 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CLACfast vs CLACslow

Time in desired SpO2 rangeScale: 0% to 100% of time · preterm infants with respiratory dysfunction

1 finding from 1 review

Automated oxygen delivery for preterm infants with respiratory dysfunction 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 19 participants
Low