Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Neonatal

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 16.7%Low 5 · 83.3%Moderate 0 · 0%High 0 · 0%

PaO2 in mmHg (absolute values) After 24‐25 hours · pulmonary hypertension in neonates

1 finding from 1 review

Sildenafil for pulmonary hypertension in neonates 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 57 participants
Low

Change in oxygenation index ‐ After 24 hours of treatment · pulmonary hypertension in neonates

1 finding from 1 review

Sildenafil for pulmonary hypertension in neonates 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Low

All‐cause mortality · pulmonary hypertension in neonates

Sildenafil may leads to lower all‐cause mortality compared with placebo (low certainty).

1 finding from 1 review

Sildenafil for pulmonary hypertension in neonates 2017 · Cochrane Headline outcomes only
RR 0.2 [0.07, 0.56]
3 studies · 77 participants
Low

All‐cause mortality · pulmonary hypertension in neonates

It is very uncertain whether sildenafil changes all‐cause mortality compared with active control (very low certainty).

1 finding from 1 review

Sildenafil for pulmonary hypertension in neonates 2017 · Cochrane Headline outcomes only
RR 0.55 [0.05, 5.75]
1 study · 65 participants
Very low

All‐cause mortality · pulmonary hypertension in neonates

Sildenafil plus iNO showed no clear difference in all‐cause mortality compared with placebo plus iNO (low certainty).

1 finding from 1 review

Sildenafil for pulmonary hypertension in neonates 2017 · Cochrane Headline outcomes only
RR 1.27 [0.26, 6.28]
1 study · 24 participants
Low

Length of hospital stay · pulmonary hypertension in neonates

1 finding from 1 review

Sildenafil for pulmonary hypertension in neonates 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Low