Findings

What do systematic reviews say?

19 questions · 19 findings · 2 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

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No studies found 3 · 15.8%GRADE not reported 0 · 0%Very low 7 · 36.8%Low 1 · 5.3%Moderate 2 · 10.5%High 6 · 31.6%

Selenium vs no intervention

Mean GI symptom scores · Women undergoing RT for gynecological cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Selenium vs no intervention

Acute and late GI toxicity (grade 2+) · Women undergoing RT for gynecological cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Selenium vs no intervention

Diarrhoea (grade 2+) · Women undergoing RT for gynecological cancer

Summary of findings: Selenium may leads to lower diarrhoea (grade 2+) compared with no intervention (low certainty).

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
RR 0.4
1 study · 81 participants
Low

Selenium vs no intervention

QoL · Women undergoing RT for gynecological cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Highest vs lowest selenium exposure

Mortality: all cancers · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes cancer mortality risk No. of participants: 183,863 (7 observational… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Selenium for preventing cancer 2018 · Cochrane Headline outcomes only
OR 0.76 [0.59, 0.97]
Studies not reported
Very low

Highest vs lowest selenium exposure

Colorectal cancer risk (16 studies) · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes colorectal cancer risk No. of participants: 712,746 (6 observational… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Selenium for preventing cancer 2018 · Cochrane Headline outcomes only
OR 0.82 [0.72, 0.94]
Studies not reported
Very low

Highest vs lowest selenium exposure

Lung cancer risk (17 studies) · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes lung cancer risk No. of participants: 371,067 (11 observational… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Selenium for preventing cancer 2018 · Cochrane Headline outcomes only
OR 0.82 [0.59, 1.14]
Studies not reported
Very low

Highest vs lowest selenium exposure

Breast cancer risk (14 studies) · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes breast cancer risk (women) No. of participants: 169,028 (8… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Selenium for preventing cancer 2018 · Cochrane Headline outcomes only
OR 1.09 [0.87, 1.37]
Studies not reported
Very low

Highest vs lowest selenium exposure

Bladder cancer risk No. of participants: 279,100 (5 observational studies) · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes bladder cancer risk No. of participants: 279,100 (5 observational… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Selenium for preventing cancer 2018 · Cochrane Headline outcomes only
OR 0.67 [0.46, 0.97]
Studies not reported
Very low

Highest vs lowest selenium exposure

Prostate cancer risk (13 studies) · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes prostate cancer risk No. of participants: 576,667 (21 observational… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Selenium for preventing cancer 2018 · Cochrane Headline outcomes only
OR 0.84 [0.75, 0.95]
Studies not reported
Very low

Highest vs lowest selenium exposure

Any cancer risk No. of participants: 76,239 (7 observational studies) · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes any cancer risk No. of participants: 76,239 (7 observational studies) compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Selenium for preventing cancer 2018 · Cochrane Headline outcomes only
OR 0.72 [0.55, 0.93]
Studies not reported
Very low

Highest vs lowest selenium exposure

Any cancer risk No. of participants: 19,475 (3 RCTs) · Participants in trials with low risk of bias

Highest showed no clear difference in any cancer risk No. of participants: 19,475 (3 RCTs) compared with lowest selenium exposure (high certainty).

1 finding from 1 review

Selenium for preventing cancer 2018 · Cochrane Headline outcomes only
RR 1.01 [0.93, 1.1]
Studies not reported
High

Highest vs lowest selenium exposure

Cancer mortality risk No. of participants: 17,448 (1 RCT) · Participants in trials with low risk of bias

Highest showed no clear difference in cancer mortality risk No. of participants: 17,448 (1 RCT) compared with lowest selenium exposure (high certainty).

1 finding from 1 review

Selenium for preventing cancer 2018 · Cochrane Headline outcomes only
RR 1.02 [0.8, 1.3]
Studies not reported
High

Highest vs lowest selenium exposure

Colorectal cancer risk (16 studies) · Participants in trials with low risk of bias

Highest showed no clear difference in colorectal cancer risk No. of participants: 19,009 (2 RCTs) compared with lowest selenium exposure (high certainty).

1 finding from 1 review

Selenium for preventing cancer 2018 · Cochrane Headline outcomes only
RR 0.99 [0.69, 1.43]
Studies not reported
High

Highest vs lowest selenium exposure

Non‐melanoma skin cancer risk No. of participants: 2027 (2 RCTs) · Participants in trials with low risk of bias

Highest showed no clear difference in non‐melanoma skin cancer risk No. of participants: 2027 (2 RCTs) compared with lowest selenium exposure (moderate certainty).

1 finding from 1 review

Selenium for preventing cancer 2018 · Cochrane Headline outcomes only
RR 1.16 [0.3, 4.42]
Studies not reported
Moderate

Highest vs lowest selenium exposure

Lung cancer risk (17 studies) · Participants in trials with low risk of bias

Highest showed no clear difference in lung cancer risk No. of participants: 19,009 (2 RCTs) compared with lowest selenium exposure (high certainty).

1 finding from 1 review

Selenium for preventing cancer 2018 · Cochrane Headline outcomes only
RR 1.16 [0.89, 1.5]
Studies not reported
High

Highest vs lowest selenium exposure

Breast cancer risk (14 studies) · Participants in trials with low risk of bias

Highest showed no clear difference in breast cancer risk No. of participants: 802 (1 RCT) compared with lowest selenium exposure (moderate certainty).

1 finding from 1 review

Selenium for preventing cancer 2018 · Cochrane Headline outcomes only
RR 2.04 [0.44, 9.55]
Studies not reported
Moderate

Highest vs lowest selenium exposure

Bladder cancer risk No. of participants: 19,009 (2 RCTs) · Participants in trials with low risk of bias

Highest showed no clear difference in bladder cancer risk No. of participants: 19,009 (2 RCTs) compared with lowest selenium exposure (high certainty).

1 finding from 1 review

Selenium for preventing cancer 2018 · Cochrane Headline outcomes only
RR 1.07 [0.76, 1.52]
Studies not reported
High

Highest vs lowest selenium exposure

Prostate cancer risk (13 studies) · Participants in trials with low risk of bias

Highest showed no clear difference in prostate cancer risk No. of participants: 18,942 (4 RCTs) compared with lowest selenium exposure (high certainty).

1 finding from 1 review

Selenium for preventing cancer 2018 · Cochrane Headline outcomes only
RR 1.01 [0.9, 1.14]
Studies not reported
High