Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Urology

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 5 · 71.4%High 0 · 0%

Participant perception of change with treatment · adult men with premature ejaculation

SSRI probably leads to higher participant perception of change with treatment compared with placebo (moderate certainty).

1 finding from 1 review

Selective serotonin re‐uptake inhibitors for premature ejaculation in adult men 2021 · Cochrane Headline outcomes only
RR 1.92 [1.66, 2.23]
6 studies · 3260 participants
Moderate

Participant satisfaction with intercourse · adult men with premature ejaculation

SSRI probably leads to higher participant satisfaction with intercourse compared with placebo (moderate certainty).

1 finding from 1 review

Selective serotonin re‐uptake inhibitors for premature ejaculation in adult men 2021 · Cochrane Headline outcomes only
RR 1.63 [1.42, 1.87]
3 studies · 4273 participants
Moderate

Withdrawals due to adverse events · adult men with premature ejaculation

SSRI may leads to higher study withdrawal due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Selective serotonin re‐uptake inhibitors for premature ejaculation in adult men 2021 · Cochrane Headline outcomes only
RR 3.8 [2.61, 5.51]
20 studies · 7367 participants
Low

Perceived control over ejaculation · adult men with premature ejaculation

SSRI probably leads to higher perceived control over ejaculation compared with placebo (moderate certainty).

1 finding from 1 review

Selective serotonin re‐uptake inhibitors for premature ejaculation in adult men 2021 · Cochrane Headline outcomes only
RR 2.29 [1.72, 3.05]
3 studies · 4273 participants
Moderate

Participant distress about PE · adult men with premature ejaculation

SSRI probably leads to higher participant distress about PE compared with placebo (moderate certainty).

1 finding from 1 review

Selective serotonin re‐uptake inhibitors for premature ejaculation in adult men 2021 · Cochrane Headline outcomes only
RR 1.54 [1.26, 1.88]
1 study · 652 participants
Moderate

Adverse events · adult men with premature ejaculation

SSRI probably leads to higher adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Selective serotonin re‐uptake inhibitors for premature ejaculation in adult men 2021 · Cochrane Headline outcomes only
RR 1.71 [1.48, 1.99]
17 studies · 4624 participants
Moderate

IELT · adult men with premature ejaculation

1 finding from 1 review

Selective serotonin re‐uptake inhibitors for premature ejaculation in adult men 2021 · Cochrane Headline outcomes only
no estimate extracted
20 studies · 5872 participants
Low