Findings

What do systematic reviews say?

22 questions · 22 findings · 1 reviews

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No studies found 8 · 36.4%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 13.6%Moderate 6 · 27.3%High 5 · 22.7%

Closest answers

The findings closest to your search, judged one by one by TypeSafe's Jev model.

Direct match · question page
- Second trimester amniocentesis vs control · Spontaneous miscarriage
  Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
  RR 1.6 [1.02, 2.52]
  1 study · 4606 participants
  High
Direct match · question page
- Second trimester amniocentesis vs control · All known pregnancy loss (including termination of pregnancy)
  Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
  RR 1.41 [0.99, 2]
  1 study · 4606 participants
  Moderate
Direct match · question page
- Second trimester amniocentesis vs control · Anomalies (all recorded)
  Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
  RR 0.93 [0.62, 1.39]
  1 study · 4507 participants
  Moderate
Direct match · question page
- Second trimester amniocentesis vs control · Delivery before 33 weeks
  Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
Direct match · question page
- Second trimester amniocentesis vs control · Sampling failure
  Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Second trimester amniocentesis vs control

All known pregnancy loss (including termination of pregnancy) · prenatal diagnosis

Second trimester amniocentesis showed no clear difference in all known pregnancy loss (including termination of pregnancy) compared with control (moderate certainty).

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
RR 1.41 [0.99, 2]
1 study · 4606 participants
Moderate

Second trimester amniocentesis vs control

Miscarriage · prenatal diagnosis

Second trimester amniocentesis leads to higher spontaneous miscarriage compared with control (high certainty).

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
RR 1.6 [1.02, 2.52]
1 study · 4606 participants
High

Second trimester amniocentesis vs control

Sampling failure · prenatal diagnosis

The review found no eligible studies for this question.

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Second trimester amniocentesis vs control

Laboratory failure · prenatal diagnosis

Second trimester amniocentesis leads to higher laboratory failure compared with control (high certainty).

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
RR 27.02 [1.61, 454.31]
1 study · 4606 participants
High

Second trimester amniocentesis vs control

Known false negative after birth · prenatal diagnosis

The review found no eligible studies for this question.

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Second trimester amniocentesis vs control

Delivery before 33 weeks · prenatal diagnosis

The review found no eligible studies for this question.

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Second trimester amniocentesis vs control

Anomalies (all recorded) · prenatal diagnosis

Second trimester amniocentesis showed no clear difference in anomalies (all recorded) compared with control (moderate certainty).

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
RR 0.93 [0.62, 1.39]
1 study · 4507 participants
Moderate

Early vs second trimester amniocentesis

Sampling failure · prenatal diagnosis

Early showed no clear difference in sampling failure compared with second trimester amniocentesis (moderate certainty).

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
RR 4.53 [0.53, 38.56]
1 study · 629 participants
Moderate

Early vs second trimester amniocentesis

Laboratory failure · prenatal diagnosis

Early leads to higher laboratory failure compared with second trimester amniocentesis (high certainty).

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
RR 9.76 [3.49, 27.26]
1 study · 4368 participants
High

Early vs second trimester amniocentesis

Known false negative after birth · prenatal diagnosis

Early showed no clear difference in known false negative after birth compared with second trimester amniocentesis (moderate certainty).

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
RR 3 [0.12, 73.67]
1 study · 4368 participants
Moderate

Early vs second trimester amniocentesis

Known false negative after birth ‐ Incorrect sex determination · prenatal diagnosis

Early showed no clear difference in known false negative after birth ‐ Incorrect sex determination compared with second trimester amniocentesis (moderate certainty).

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
RR 5 [0.24, 104.18]
1 study · 4368 participants
Moderate

Early vs second trimester amniocentesis

Delivery before 33 weeks · prenatal diagnosis

The review found no eligible studies for this question.

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Early vs second trimester amniocentesis

Anomalies (all recorded) · prenatal diagnosis

Early leads to higher anomalies (all recorded) compared with second trimester amniocentesis (high certainty).

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
RR 1.73 [1.26, 2.38]
1 study · 4334 participants
High

Transabdominal chorionic villus sampling vs second trimester amniocentesis

All known pregnancy loss (including termination of pregnancy) · prenatal diagnosis

Transabdominal chorionic villus sampling showed no clear difference in all known pregnancy loss (including termination of pregnancy) compared with second trimester amniocentesis (low certainty).

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
RR 0.9 [0.66, 1.23]
1 study · 2234 participants
Low

Transabdominal chorionic villus sampling vs second trimester amniocentesis

Miscarriage · prenatal diagnosis

Transabdominal chorionic villus sampling showed no clear difference in spontaneous miscarriage compared with second trimester amniocentesis (low certainty).

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
RR 0.77 [0.49, 1.21]
1 study · 2069 participants
Low

Transabdominal chorionic villus sampling vs second trimester amniocentesis

Sampling failure · prenatal diagnosis

The review found no eligible studies for this question.

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Transabdominal chorionic villus sampling vs second trimester amniocentesis

Laboratory failure · prenatal diagnosis

The review found no eligible studies for this question.

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Transabdominal chorionic villus sampling vs second trimester amniocentesis

Known false negative after birth · prenatal diagnosis

The review found no eligible studies for this question.

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Transabdominal chorionic villus sampling vs second trimester amniocentesis

Delivery before 33 weeks · prenatal diagnosis

The review found no eligible studies for this question.

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Transabdominal chorionic villus sampling vs second trimester amniocentesis

Perinatal death (stillbirth + death in first week of life) · prenatal diagnosis

Transabdominal chorionic villus sampling showed no clear difference in perinatal deaths (stillbirths and neonatal deaths in the first week… compared with second trimester amniocentesis (low certainty).

1 finding from 1 review

Amniocentesis and chorionic villus sampling for prenatal diagnosis 2017 · Cochrane Headline outcomes only
RR 1.18 [0.4, 3.51]
1 study · 2069 participants
Low