Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

7 questions · 7 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 7 · 100%Moderate 0 · 0%High 0 · 0%

SLNB vs observation

Rate of development of distant metastases following SLNB and curative CLND First pathologically confirmed distant metastasis · patients with localised primary cutaneous melanoma

SLNB may leads to higher rate of development of distant metastases following SLNB and… compared with observation (low certainty).

1 finding from 1 review

SLNB vs observation

Overall Survival Intention‐to‐treat Death from any cause during the study · patients with localised primary cutaneous melanoma

SLNB showed no clear difference in overall Survival Intention‐to‐treat Death from any cause during the… compared with observation (low certainty).

1 finding from 1 review

SLNB vs observation

Surgical Morbidity (Within 30 d) Related to the Regional Nodal Basin in Patients Assigned to the 2 Treatment Arms of MSLT‐I Any complication in the dissected basin, regional or systemic related to the surgical treatment in the regional nodal basin · patients with localised primary cutaneous melanoma

SLNB may leads to higher surgical Morbidity (Within 30 d) Related to the Regional Nodal Basin… compared with observation (low certainty).

1 finding from 1 review

SLNB vs observation

Surgical Morbidity (Within 30 d) Related to Wide Excision of the Primary Site in Patients Assigned to the 2 Treatment Arms of MSLT‐I Any Surgical Complication related to the wide excision site · patients with localised primary cutaneous melanoma

SLNB showed no clear difference in surgical Morbidity (Within 30 d) Related to Wide Excision of the… compared with observation (low certainty).

1 finding from 1 review