Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

88 questions · 90 findings · 13 reviews · Skin · Headline outcomes only

No studies found 11 · 12.2%GRADE not reported 4 · 4.4%Very low 27 · 30%Low 32 · 35.6%Moderate 14 · 15.6%High 2 · 2.2%

Valaciclovir (short‐term) vs placebo

Incidence of herpes labialis after use of the preventative intervention · participants with recurrent herpes labialis

Valaciclovir (short‐term) showed no clear difference in incidence of HSL during use of the preventative intervention (by… compared with placebo (moderate certainty).

1 finding from 1 review

Valaciclovir (short‐term) vs placebo

Incidence of HSL during use of the preventative intervention (by culture) · participants with recurrent herpes labialis

Valaciclovir (short‐term) showed no clear difference in incidence of HSL during use of the preventative intervention (by… compared with placebo (moderate certainty).

1 finding from 1 review

Valaciclovir (short‐term) vs placebo

Adverse effects during use of the preventative intervention · participants with recurrent herpes labialis

Valaciclovir (short‐term) showed no clear difference in adverse effects during use of the preventative intervention compared with placebo (moderate certainty).

1 finding from 1 review

Oral aciclovir (short‐term) vs placebo

Incidence of herpes labialis after use of the preventative intervention · participants with recurrent herpes labialis

Oral aciclovir (short‐term) showed no clear difference in incidence of herpes labialis during use of the preventative… compared with placebo (moderate certainty).

1 finding from 1 review

Oral aciclovir (short‐term) vs placebo

Incidence of herpes labialis during use of the preventative intervention · participants with recurrent herpes labialis

Oral aciclovir (short‐term) may leads to lower incidence of herpes labialis during use of the preventative… compared with placebo (low certainty).

1 finding from 1 review

Oral aciclovir (short‐term) vs placebo

Incidence of herpes labialis during use of the preventative intervention (by clinical evaluation) ‐ aciclovir 200 mg 5 times/day · participants with recurrent herpes labialis

Oral aciclovir (short‐term) showed no clear difference in incidence of herpes labialis during use of the preventative… compared with placebo (low certainty).

1 finding from 1 review

Oral aciclovir (short‐term) vs placebo

Incidence of herpes labialis during use of the preventative intervention (by culture) ‐ aciclovir 400 mg twice daily · participants with recurrent herpes labialis

Oral aciclovir (short‐term) may leads to lower incidence of herpes labialis during use of the preventative… compared with placebo (low certainty).

1 finding from 1 review

Oral aciclovir (short‐term) vs placebo

Adverse effects during use of the preventative intervention ‐ aciclovir 800 mg twice daily · participants with recurrent herpes labialis

Oral aciclovir (short‐term) showed no clear difference in adverse effects during use of the preventative intervention ‐… compared with placebo (moderate certainty).

1 finding from 1 review

Oral aciclovir (short‐term) vs placebo

Adverse effects during use of the preventative intervention ‐ aciclovir 400 mg twice daily · participants with recurrent herpes labialis

Oral aciclovir (short‐term) showed no clear difference in adverse effects during use of the preventative intervention ‐… compared with placebo (low certainty).

1 finding from 1 review

Topical aciclovir (short‐term) vs placebo

Incidence of herpes labialis during use of the preventative intervention · participants with recurrent herpes labialis

Topical aciclovir (short‐term) showed no clear difference in incidence of herpes labialis during use of the preventative… compared with placebo (moderate certainty).

1 finding from 1 review

Topical aciclovir (short‐term) vs placebo

Adverse effects during use of the preventative intervention · participants with recurrent herpes labialis

Topical aciclovir (short‐term) showed no clear difference in adverse effects during use of the preventative intervention compared with placebo (low certainty).

1 finding from 1 review

Topical aciclovir (short‐term) vs placebo

Severity (aborted lesions) of attack of recurrent herpes labialis during use of the preventative intervention · participants with recurrent herpes labialis

Topical aciclovir (short‐term) showed no clear difference in severity (aborted lesions) of attack of recurrent herpes labialis… compared with placebo (low certainty).

1 finding from 1 review

Topical aciclovir (short‐term) vs placebo

Incidence of herpes labialis after use of the preventative intervention · participants with recurrent herpes labialis

Topical aciclovir (short‐term) may leads to lower incidence of herpes labialis after use of the preventative… compared with placebo (low certainty).

1 finding from 1 review

Topical aciclovir and 348U87 cream (short‐term) vs placebo

Incidence of herpes labialis during use of the preventative intervention · participants with recurrent herpes labialis

It is very uncertain whether topical aciclovir and 348U87 cream (short‐term) changes incidence of herpes labialis during use of the preventative… compared with placebo (very low certainty).

2 findings from 1 review

Summary of findings table ‐ Oral classical immunosuppressants (prednisolone or cyclosporine) vs placebo

Short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of · adults with alopecia areata

It is very uncertain whether summary of findings table ‐ Oral classical immunosuppressants… changes short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Subcutaneous biologics (dupilumab) vs placebo

Short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of · adults with alopecia areata

Summary of findings table ‐ Subcutaneous biologics (dupilumab) showed no clear difference in short‐term hair regrowth ≥ 75% compared with placebo (low certainty).

1 finding from 1 review

Summary of findings table ‐ Oral small molecule inhibitors (apremilast or baricitinib) vs placebo

Short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of · adults with alopecia areata

Summary of findings table ‐ Oral small molecule inhibitors… leads to higher short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of compared with placebo (high certainty).

1 finding from 1 review