What do systematic reviews say?

Short‐acting insulin analogues vs regular human insulin

Short‐acting insulin analogues showed no clear difference in all‐cause mortality (N) compared with regular human insulin (moderate certainty).

• Short‐acting insulin analogues versus regular human insulin for adult, non‐pregnant persons with type 2 diabetes… 2018 · Cochrane Headline outcomes only
  Peto OR 1.66 [0.41, 6.64]
  6 studies · 2519 participants
  Moderate
• Short‐acting insulin analogues versus regular human insulin for adults with type 1 diabetes mellitus 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Short‐acting insulin analogues vs regular human insulin

• Short‐acting insulin analogues versus regular human insulin for adult, non‐pregnant persons with type 2 diabetes… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 2509 participants
  Low
• Short‐acting insulin analogues versus regular human insulin for adults with type 1 diabetes mellitus 2016 · Cochrane Headline outcomes only
  OR 0.89 [0.71, 1.12]
  7 studies · 2459 participants
  Very low

Short‐acting insulin analogues vs regular human insulin

• Short‐acting insulin analogues versus regular human insulin for adult, non‐pregnant persons with type 2 diabetes… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 2608 participants
  Low
• Short‐acting insulin analogues versus regular human insulin for adults with type 1 diabetes mellitus 2016 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 2608 participants
  Low

Short‐acting insulin analogues vs regular human insulin

• Short‐acting insulin analogues versus regular human insulin for adult, non‐pregnant persons with type 2 diabetes… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 2 participants
  Very low
• Short‐acting insulin analogues versus regular human insulin for adults with type 1 diabetes mellitus 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin vs placebo or no treatment

It is very uncertain whether metformin changes clinical pregnancy rate per woman ‐ short protocol GnRH‐antagonist compared with placebo or no treatment (very low certainty).

• Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome 2020 · Cochrane Headline outcomes only
  RR 1.38 [0.21, 9.14]
  2 studies · 177 participants
  Very low