Findings

What do systematic reviews say?

5 questions · 7 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 1 · 14.3%High 5 · 71.4%

Severe cases of rotavirus diarrhoea · children

Rotasiil leads to lower severe cases of rotavirus diarrhoea compared with placebo (high certainty).

2 findings from 1 review

Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.52 [0.33, 0.81]
2 studies · 11008 participants
High
Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.56 [0.42, 0.74]
2 studies · 11008 participants
High

Severe cases of all‐cause diarrhoea · children

Rotasiil showed no clear difference in severe cases of all‐cause diarrhoea compared with placebo (high certainty).

2 findings from 1 review

Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.92 [0.84, 1.01]
2 studies · 11008 participants
High
Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.94 [0.88, 1.01]
2 studies · 11008 participants
High

All‐cause death · children

Rotasiil showed no clear difference in all‐cause death compared with placebo (moderate certainty).

1 finding from 1 review

Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 1.14 [0.82, 1.59]
2 studies · 11586 participants
Moderate

All serious adverse events · children

Rotasiil showed no clear difference in all serious adverse events compared with placebo (high certainty).

1 finding from 1 review

Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.98 [0.92, 1.04]
3 studies · 11646 participants
High

Serious adverse events: intussusception · children

Rotasiil showed no clear difference in serious adverse events: intussusception compared with placebo (low certainty).

1 finding from 1 review

Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only
RR 0.98 [0.35, 2.74]
2 studies · 11586 participants
Low