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What do systematic reviews say?

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Evidence found and GRADE certainty

14 questions · 14 findings · 2 reviews

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No studies found 6 · 42.9%GRADE not reported 0 · 0%Very low 4 · 28.6%Low 4 · 28.6%Moderate 0 · 0%High 0 · 0%

RhDNase vs placebo

Adverse events · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

RhDNase vs placebo

Health‐related quality of life · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

RhDNase vs placebo

Symptoms sputum colour Scale used not reported · people with bronchiectasis

RhDNase showed no clear difference in symptoms sputum colour Scale used not reported compared with placebo (low certainty).

1 finding from 1 review

RhDNase vs placebo

Deaths · people with bronchiectasis

RhDNase showed no clear difference in deaths compared with placebo (low certainty).

1 finding from 1 review

RhDNase vs placebo

Lung function: FEV1 mL (percentage change from baseline) · people with bronchiectasis

RhDNase showed no clear difference in lung function % change FEV1 compared with placebo (low certainty).

1 finding from 1 review

RhDNase vs placebo

Frequency and duration of exacerbations · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

RhDNase vs placebo

Hospitalisations for infective exacerbations · people with bronchiectasis

RhDNase showed no clear difference in hospitalisations for infective exacerbations compared with placebo (low certainty).

1 finding from 1 review