Findings

What do systematic reviews say?

35 questions · 35 findings · 4 reviews · Infectious Diseases

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No studies found 8 · 22.9%GRADE not reported 0 · 0%Very low 5 · 14.3%Low 4 · 11.4%Moderate 10 · 28.6%High 8 · 22.9%

Closest answers

The findings closest to your search, judged one by one by TypeSafe's Jev model.

Direct match · question page
- Resistance testing vs no resistance testing · Virological failure
  Antiretroviral resistance testing in HIV‐positive people 2018 · Cochrane Headline outcomes only
  OR 0.7 [0.56, 0.87]
  10 studies · 1728 participants
  Low
Direct match · question page
- Resistance testing vs no resistance testing · Progression to AIDS
  Antiretroviral resistance testing in HIV‐positive people 2018 · Cochrane Headline outcomes only
  OR 0.64 [0.31, 1.29]
  3 studies · 809 participants
  Moderate
Direct match · question page
- Resistance testing vs no resistance testing · Change in viral load
  Antiretroviral resistance testing in HIV‐positive people 2018 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 1837 participants
  Moderate
Direct match · question page
- Resistance testing vs no resistance testing · Mortality
  Antiretroviral resistance testing in HIV‐positive people 2018 · Cochrane Headline outcomes only
  OR 0.89 [0.36, 2.22]
  5 studies · 1140 participants
  Moderate
Direct match · question page
- Resistance testing vs no resistance testing · Change in CD4 cell count
  Antiretroviral resistance testing in HIV‐positive people 2018 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 1349 participants
  Moderate

Resistance testing vs no resistance testing

All‐cause mortality · HIV‐positive people

Resistance testing showed no clear difference in mortality compared with no resistance testing (moderate certainty).

1 finding from 1 review

Antiretroviral resistance testing in HIV‐positive people 2018 · Cochrane Headline outcomes only
OR 0.89 [0.36, 2.22]
5 studies · 1140 participants
Moderate

Resistance testing vs no resistance testing

Virological failure · HIV‐positive people

Resistance testing may leads to lower virological failure compared with no resistance testing (low certainty).

1 finding from 1 review

Antiretroviral resistance testing in HIV‐positive people 2018 · Cochrane Headline outcomes only
OR 0.7 [0.56, 0.87]
10 studies · 1728 participants
Low

Resistance testing vs no resistance testing

Change in CD4 count · HIV‐positive people

1 finding from 1 review

Antiretroviral resistance testing in HIV‐positive people 2018 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 1349 participants
Moderate

Resistance testing vs no resistance testing

Progression to AIDS · HIV‐positive people

Resistance testing showed no clear difference in progression to AIDS compared with no resistance testing (moderate certainty).

1 finding from 1 review

Antiretroviral resistance testing in HIV‐positive people 2018 · Cochrane Headline outcomes only
OR 0.64 [0.31, 1.29]
3 studies · 809 participants
Moderate

Resistance testing vs no resistance testing

Adverse events · HIV‐positive people

Resistance testing showed no clear difference in adverse events compared with no resistance testing (low certainty).

1 finding from 1 review

Antiretroviral resistance testing in HIV‐positive people 2018 · Cochrane Headline outcomes only
OR 0.89 [0.51, 1.55]
4 studies · 808 participants
Low

Resistance testing vs no resistance testing

Change in viral load · HIV‐positive people

1 finding from 1 review

Antiretroviral resistance testing in HIV‐positive people 2018 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 1837 participants
Moderate

Resistance testing vs no resistance testing

Quality of life ‐ not reported · HIV‐positive people

The review found no eligible studies for this question.

1 finding from 1 review

Antiretroviral resistance testing in HIV‐positive people 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Resistance testing vs no resistance testing

New opportunistic infection ‐ not reported · HIV‐positive people

The review found no eligible studies for this question.

1 finding from 1 review

Antiretroviral resistance testing in HIV‐positive people 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

False positivespeople incorrectly classified as having isoniazid resistance · adults with pulmonary tuberculosis irrespective of rifampicin resistance (i.e. whether or not their rifampicin resistance status was…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 327 participants
Moderate

Intervention not reported

True positivespeople with fluoroquinolone resistance · adults with pulmonary tuberculosis irrespective of rifampicin resistance (i.e. whether or not their rifampicin resistance status was…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 381 participants
High

Intervention not reported

False negativespeople incorrectly classified as not having fluoroquinolone resistance · adults with pulmonary tuberculosis irrespective of rifampicin resistance (i.e. whether or not their rifampicin resistance status was…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 381 participants
High

Intervention not reported

True negativespeople without fluoroquinolone resistance · adults with pulmonary tuberculosis irrespective of rifampicin resistance (i.e. whether or not their rifampicin resistance status was…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 640 participants
Moderate

Intervention not reported

False positivespeople incorrectly classified as having fluoroquinolone resistance · adults with pulmonary tuberculosis irrespective of rifampicin resistance (i.e. whether or not their rifampicin resistance status was…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 640 participants
Moderate

Intervention not reported

True positivespeople with ethionamide resistance · adults with pulmonary tuberculosis with known rifampicin resistance, detected as tuberculosis positive by Xpert MTB/XDRRole: an initial…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 167 participants
Very low

Intervention not reported

False negativespeople incorrectly classified as not having ethionamide resistance · adults with pulmonary tuberculosis with known rifampicin resistance, detected as tuberculosis positive by Xpert MTB/XDRRole: an initial…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 167 participants
Very low

Intervention not reported

True negativespeople without ethionamide resistance · adults with pulmonary tuberculosis with known rifampicin resistance, detected as tuberculosis positive by Xpert MTB/XDRRole: an initial…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 267 participants
Very low

Intervention not reported

False positivespeople incorrectly classified as having ethionamide resistance · adults with pulmonary tuberculosis with known rifampicin resistance, detected as tuberculosis positive by Xpert MTB/XDRRole: an initial…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 267 participants
Very low

Intervention not reported

True positivespeople with amikacin resistance · adults with pulmonary tuberculosis with known rifampicin resistance, detected as tuberculosis‐positive by Xpert MTB/XDR Index test: Xpert…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 65 participants
Low

Intervention not reported

False negativespeople incorrectly classified as not having amikacin resistance · adults with pulmonary tuberculosis with known rifampicin resistance, detected as tuberculosis‐positive by Xpert MTB/XDR Index test: Xpert…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 65 participants
Low

Intervention not reported

True negativespeople without amikacin resistance · adults with pulmonary tuberculosis with known rifampicin resistance, detected as tuberculosis‐positive by Xpert MTB/XDR Index test: Xpert…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 425 participants
High