Cochrane · systematic review · CD006495
Antiretroviral resistance testing in HIV‐positive people
Aves, T, Tambe, J, Siemieniuk, RAC, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
6
No studies
2
Included studies
NR
No studies 2 · 25%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 25%Moderate 4 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Resistance testing versus no resistance testing in HIV‐positive people
Population: HIV‐positive people
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Resistance testing vs no resistance testing | OR 0.89 [0.36, 2.22] | 5 studies · 1140 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Virological failure Resistance testing vs no resistance testing | OR 0.7 [0.56, 0.87] | 10 studies · 1728 participants | Low Downgraded: risk of bias, imprecision, indirectness, publication bias |
Change in CD4 cell count Resistance testing vs no resistance testing | no estimate extracted | 7 studies · 1349 participants | Moderate Downgraded: risk of bias, indirectness, publication bias |
Progression to AIDS Resistance testing vs no resistance testing | OR 0.64 [0.31, 1.29] | 3 studies · 809 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Adverse events Resistance testing vs no resistance testing | OR 0.89 [0.51, 1.55] | 4 studies · 808 participants | Low Downgraded: risk of bias, imprecision, indirectness, publication bias |
Change in viral load Resistance testing vs no resistance testing | no estimate extracted | 10 studies · 1837 participants | Moderate Downgraded: risk of bias, indirectness, publication bias |
Quality of life ‐ not reported Resistance testing vs no resistance testing | no estimate extracted | NR | No studies |
New opportunistic infection ‐ not reported Resistance testing vs no resistance testing | no estimate extracted | NR | No studies |