Retention-to-caries risk ratio (RCR) · Patients with fissure-sealed permanent molar teeth
In the sensitivity analysis, the difference in retention-to-caries risk ratio between resin- and glass-ionomer cement-based sealants was not statistically significant (p = 0.069; ungraded).
2 findings from 1 review
Mean RCR (retention-to-caries risk ratio); t-test of difference Resin vs GIC difference not statistically significant (p=0.069); sensitivity-analysis mean RCRs not reported
14 studies
GRADE not reported
Mean RCR (retention-to-caries risk ratio); t-test of difference Resin mean RCR 9.64 (SD 24.58) vs GIC 13.68 (SD 13.72); p=0.017
62 studies
GRADE not reported
Association between loss of complete retention risk and caries occurrence risk · Patients with fissure-sealed permanent molar teeth
Loss of complete sealant retention was directly associated with caries occurrence for resin-based sealants in the main analysis (regression slope 0.89, 95% CI 0.56 to 1.23; ungraded).
2 findings from 1 review
Regression slope (ln caries risk on ln retention-loss risk) 0.89 [0.56, 1.23]
54 studies · 17377 participants
GRADE not reported
Regression slope (ln caries risk on ln retention-loss risk) 0.53 [-0.27, 1.32]
14 studies · 3154 participants
GRADE not reported
Development of carious lesions on sealed occlusal pits and fissures · Children with fully erupted permanent first molar teeth (mean age about 6 to 8 years)
At 48 months, no statistically significant difference was found between HVGIC and resin-based sealants (RR 0.62, 95% CI 0.31 to 1.21); evidence ungraded and at high risk of bias.
4 findings from 1 review
RR 0.62 [0.31, 1.21]
2 studies · 1007 evaluated sealed teeth participants
GRADE not reported
RR 0.29 [0.09, 0.95]
2 studies · 205 evaluated sealed teeth participants
GRADE not reported
RR 0.90 [0.49, 1.67]
3 studies · 600 evaluated sealed teeth participants
GRADE not reported
Show 1 more finding
DMFS (decayed, missing, filled surfaces) increment, occlusal surfaces · Schoolchildren aged 6-12 years with sound occlusal surfaces of the first permanent molars
Pit and fissure sealant and fluoride varnish showed no statistically significant difference in DMFS increment at 24 months (SMD -0.13, 95% CI -0.67 to 0.40; I2=92%; not GRADE-rated).
1 finding from 1 review
Caries incidence of first permanent molars (FPMs) · Schoolchildren aged 6-12 years with sound occlusal surfaces of the first permanent molars
Pit and fissure sealant and fluoride varnish showed no statistically significant difference in caries incidence of first permanent molars at 24 months (RR 0.65, 95% CI 0.31 to 1.38; I2=89%; not GRADE-rated).
1 finding from 1 review
Caries occurrence on sealed teeth · Sealed permanent teeth
Glass-ionomer and resin-based fissure sealants showed no statistically significant difference in caries occurrence on sealed permanent teeth at 12 months (no GRADE rating).
3 findings from 1 review
RR 1.66 [0.75, 3.68]
5 studies · 1952 participants
GRADE not reported
RR 2.04 [0.62, 6.70]
6 studies · 1944 participants
GRADE not reported
RR 1.51 [1.00, 2.28]
8 studies · 2810 participants
GRADE not reported
Caries incidence of first permanent molars (FPMs) · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures or early enamel…
After excluding the high-risk-of-bias study (Bravo 1996), fluoride varnish and fissure sealant did not differ in caries incidence of FPMs and heterogeneity fell to 0% (RR 1.05, 95% CI 0.91 to 1.22; 5 RCTs; ungraded).
3 findings from 1 review
Caries incidence (proportion of enrolled children developing dentin caries, ICDAS 4-6) · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures or early enamel…
Fluoride varnish and fissure sealant did not differ significantly in the proportion of children developing caries at 2 to 3 years (RR 1.12, 95% CI 0.60 to 2.09; 2 RCTs; ungraded).
1 finding from 1 review
Caries incidence of occlusal surfaces of first permanent molars · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures or early enamel…
After excluding Bravo 1996, occlusal caries incidence slightly favored fluoride varnish but was not significant, with heterogeneity falling to 0% (RR 0.98, 95% CI 0.82 to 1.16; 3 RCTs; ungraded).
2 findings from 1 review
Increment of occlusal DMFS (decayed, missing, filled surfaces) of FPMs · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures or early enamel…
Fluoride varnish and fissure sealant did not differ significantly in occlusal DMFS increment of FPMs (MD 0.13, 95% CI -0.09 to 0.34; 3 RCTs; ungraded).
2 findings from 1 review
Intervention not reported
Development of carious lesions on sealed occlusal pits and fissures
The intervention led to lower development of carious lesions on sealed occlusal pits and fissures; GRADE not reported.
1 finding from 1 review
RD -0.07 [-0.14, -0.01]
2 studies
GRADE not reported