Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 2 · 66.7%Very low 1 · 33.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

MMP-2 expression/activity · Human ex vivo carious dentin (head/neck radiotherapy)

MMP-2 showed no difference between irradiated and non-irradiated carious dentin (one study; ungraded).

1 finding from 1 review

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
Ex vivo (extracted teeth / clinical carious or biofilm samples)
No significant difference in MMP-2 (gelatinase) expression or activity between irradiated and non-irradiated groups (Gomes-Silva et al., 2017a); GRADE not separately applied to this comparison.
1 study · 36 participants
GRADE not reported

MMP-9 expression/activity · Human ex vivo carious dentin (head/neck radiotherapy)

MMP-9 showed no increase in irradiated vs non-irradiated carious dentin (one study; ungraded).

1 finding from 1 review

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
Ex vivo (extracted teeth / clinical carious or biofilm samples)
MMP-9 predominantly positive in non-irradiated vs irradiated carious dentin (single study; ungraded)
1 study · 36 participants
GRADE not reported

MMP-20 expression · Human ex vivo carious dentin (head/neck radiotherapy)

MMP-20 shows no difference between irradiated and non-irradiated carious dentin; the evidence is very uncertain (very low certainty).

1 finding from 1 review

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
Ex vivo (extracted teeth / clinical carious or biofilm samples)
There is no difference about the MMP-20 expression in irradiated vs. non-irradiated carious dentin, but the evidence is very uncertain (Gomes-Silva et al., 2017b).
1 study · 36 participants
Very low