Ferric sulphate (FS) + mineral trioxide aggregate (MTA) vs Ferric sulphate (FS)
Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Assessed pain, soft tissue, mobility, adjacent tissue inflammation, radiolucency, root resorption, pulp canal obliteration (Doyle 2010); no clinical/radiological failure outcome; no significant differences
1 study · 135 participants
GRADE not reported
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Ferric sulphate (FS) showed no clear difference in radiological failure compared with zinc oxide and eugenol (ZOE); GRADE not reported.
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Ferric sulphate (FS) showed no clear difference in radiological failure compared with ankaferd Blood Stopper (ABS) (low certainty).
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
It is very uncertain whether ferric sulphate (FS) changes clinical failure compared with ankaferd Blood Stopper (ABS) (very low certainty).
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Ferric sulphate (FS) showed no clear difference in radiological failure compared with formocresol (FC) (low certainty).
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
Ferric sulphate (FS) showed no clear difference in clinical failure compared with formocresol (FC) (low certainty).
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
Ferric sulphate (FS) showed no clear difference in clinical failure compared with zinc oxide and eugenol (ZOE); GRADE not reported.
1 finding from 1 review
Ferric sulphate (FS) vs Buffered glutaraldehyde
Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Assessed pain, soft tissue, mobility, radiolucency, root resorption, pulp canal obliteration (Goyal 2016); no clinical/radiological failure outcome; no significant differences
1 study · 60 participants
GRADE not reported
Overall success (composite of clinical and radiographic success) · Mature permanent teeth with irreversible pulpitis and carious pulp exposure (treated with full pulpotomy)
Platelet-rich fibrin and calcium hydroxide showed no significant difference in success (ungraded; effect size not reported).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in immature permanent teeth undergoing pulpotomy
The two trials of PRF versus MTA for success gave contradictory results and were not pooled (ungraded).
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
Ferric sulphate/MTA pulpotomy showed no clear difference in clinical failure compared with zinc oxide and eugenol (ZOE) pulpectomy; GRADE not reported.
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Ferric sulphate/MTA pulpotomy showed no clear difference in radiological failure compared with zinc oxide and eugenol (ZOE) pulpectomy; GRADE not reported.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing pulpotomy
MTA and CEM performed comparably for clinical and radiographic success (2 RCTs, not pooled; ungraded).
1 finding from 1 review
Radiographic healing - 1 year · People requiring retreatment of periapical lesions (failed root canal therapy)
1 finding from 1 review
Angerame 2015 (7 test, 4 control): no significant difference in healing of the lesion at 1 year; significant difference only at 2- and 3-month follow-up. Small preliminary study; no robust pooled analysis.
1 study · 11 participants
GRADE not reported
Swelling (mean) · People requiring retreatment of periapical lesions (failed root canal therapy)
1 finding from 1 review
Postoperative pain · People requiring retreatment of periapical lesions (failed root canal therapy)
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
2 findings from 1 review
No clinical failure in any participant (Malekafzali 2011); not estimable
1 study · 80 participants
GRADE not reported
RR 3.00 [0.13, 69.70]
1 study · 42 participants
Very low
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
2 findings from 1 review
No radiological failure in any participant at 6 months; not estimable
1 study · 42 participants
Very low
RR 0.33 [0.04, 2.94]
1 study · 80 participants
GRADE not reported
Tooth survival · People with avulsed and replanted permanent (front) teeth
It is very uncertain whether hyperbaric oxygen (following replantation) changes tooth survival at 12 months compared with control (very low certainty).
1 finding from 1 review
Adverse effects · People with avulsed and replanted permanent (front) teeth
1 finding from 1 review