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Evidence found and GRADE certainty

24 questions · 26 findings · 3 reviews

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No studies found 1 · 3.8%GRADE not reported 4 · 15.4%Very low 0 · 0%Low 4 · 15.4%Moderate 13 · 50%High 4 · 15.4%

Quinine vs placebo

Number of cramps over 2 weeks · patients with muscle cramps
1 finding from 1 review

Quinine vs placebo

Cramp intensity (on 3‐point scale; 1 = mild; 2 = moderate; 3 = severe) · patients with muscle cramps
1 finding from 1 review

Quinine vs placebo

Major adverse events · patients with muscle cramps
1 finding from 1 review
  • Quinine for muscle cramps 2015 · Cochrane Headline outcomes only
    no estimate extracted
    18 studies · 1103 participants
    Moderate

Quinine vs placebo

Minor adverse events · patients with muscle cramps
1 finding from 1 review

Quinine vs vitamin E

Cramp intensity (on 3‐point scale; 1 = mild; 2 = moderate; 3 = severe) · patients with muscle cramps
1 finding from 1 review

Artemether vs Quinine

Death · Patients with severe malaria

The fixed-effect NMR reported a difference between artemether and quinine at ages 15 years or more; no GRADE assessment was reported.

2 findings from 1 review

Artesunate vs Quinine

Death · Patients with severe malaria

The fixed-effect NMR reported a difference between artesunate and quinine at every displayed average age; no GRADE assessment was reported.

2 findings from 1 review

Intervention not reported

Death · Children with severe malaria

The intervention leads to lower death (high certainty).

1 finding from 1 review

Intervention not reported

Hypoglycaemia episodes · Adults with severe malaria

The intervention leads to lower hypoglycaemia episodes (high certainty).

1 finding from 1 review

Intervention not reported

Neurological sequelae at day 28 · Children with severe malaria

The intervention showed no clear difference in neurological sequelae at day 28 (moderate certainty).

1 finding from 1 review

Intervention not reported

Neurological sequelae at discharge · Children with severe malaria

The intervention probably leads to higher neurological sequelae at discharge (moderate certainty).

1 finding from 1 review

Intervention not reported

Hypoglycaemia episodes · Children with severe malaria

The intervention leads to lower hypoglycaemia episodes (high certainty).

1 finding from 1 review