Findings

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Evidence found and GRADE certainty

17 questions · 29 findings · 6 reviews · Oral Health

No studies found 2 · 6.9%GRADE not reported 27 · 93.1%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Quantitative light-induced fluorescence (QLF) vs Reference standard (bitewing radiography, ADA classification, ICDAS II)

Occlusal caries detection: specificity · Patients (in vivo); permanent and primary teeth, occlusal surfaces

In vivo, QLF pooled specificity for occlusal caries in permanent teeth was 0.80 (3 studies; ungraded).

2 findings from 1 review

Quantitative light-induced fluorescence (QLF) vs Reference standard (histology; some ICDAS/radiography)

Occlusal caries detection: sensitivity · Extracted human teeth (in vitro); permanent and primary teeth, occlusal surfaces

In vitro, QLF pooled sensitivity for occlusal caries detection was 0.83 (5 studies; ungraded).

3 findings from 1 review

Quantitative light-induced fluorescence (QLF) vs Reference standard (histology; some ICDAS/radiography)

Proximal caries detection: sensitivity · Extracted human teeth (in vitro); permanent teeth, proximal (approximal) surfaces

In vitro, QLF pooled sensitivity for proximal caries detection was 0.83 (3 permanent-teeth studies; no primary-dentition data; ungraded).

1 finding from 1 review

Quantitative light-induced fluorescence (QLF) vs Reference standard (bitewing radiography, ADA classification, ICDAS II)

Proximal caries detection: specificity · Patients (in vivo); permanent and primary teeth, proximal (approximal) surfaces

In vivo, QLF pooled specificity for proximal caries in permanent teeth was 0.81 (3 studies; ungraded).

2 findings from 1 review

Quantitative light-induced fluorescence (QLF) vs Reference standard

detection of proximal caries · human primary or permanent teeth with dental caries lesions

QLF had pooled sensitivity of 0.83 and specificity of 0.74 for proximal caries (all dentitions, in vitro).

4 findings from 1 review
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Quantitative light-induced fluorescence (QLF) vs Reference standard (histology; some ICDAS/radiography)

Occlusal caries detection: specificity · Extracted human teeth (in vitro); permanent and primary teeth, occlusal surfaces

In vitro, QLF pooled specificity for occlusal caries in permanent teeth was 0.66 (3 studies; ungraded).

3 findings from 1 review

Quantitative light-induced fluorescence (QLF) vs Reference standard (bitewing radiography, ADA classification, ICDAS II)

Occlusal caries detection: sensitivity · Patients (in vivo); permanent and primary teeth, occlusal surfaces

In vivo, QLF pooled sensitivity for occlusal caries detection was 0.86 (4 studies; ungraded).

2 findings from 1 review

Quantitative light-induced fluorescence (QLF) vs Reference standard

detection of occlusal caries · human primary or permanent teeth with dental caries lesions

QLF had pooled sensitivity of 0.86 and specificity of 0.80 for occlusal caries (permanent dentition, in vivo).

2 findings from 1 review

Quantitative light-induced fluorescence (QLF) vs Reference standard (histology; some ICDAS/radiography)

Proximal caries detection: specificity · Extracted human teeth (in vitro); permanent teeth, proximal (approximal) surfaces

In vitro, QLF pooled specificity for proximal caries detection was 0.74 (3 permanent-teeth studies; no primary-dentition data; ungraded).

1 finding from 1 review

Quantitative light-induced fluorescence (QLF) vs Reference standard (bitewing radiography, ADA classification, ICDAS II)

Proximal caries detection: sensitivity · Patients (in vivo); permanent and primary teeth, proximal (approximal) surfaces

In vivo, QLF pooled sensitivity for proximal caries detection was 0.74 (4 studies; ungraded).

2 findings from 1 review

Quantitative light-induced fluorescence (QLF) vs Reference standard (histology, excavation, or enhanced visual examination)

Diagnostic accuracy (sensitivity, specificity) - not pooled · Permanent teeth (occlusal and smooth surfaces), with suspected caries lesions

Only 3 QLF studies were included, so no pooled estimate of QLF diagnostic accuracy could be calculated (evidence not graded).

1 finding from 1 review

Quantitative light-induced fluorescence (QLF) vs Histological validation (in vitro) or cavity preparation/biopsy (in vivo)

Occlusal caries detection accuracy · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces

No eligible QLF studies met the meta-analysis inclusion criteria (candidate QLF studies were identified but none had acceptable index/reference tests and reporting quality).

1 finding from 1 review

CPP-ACP vs Pre-treatment (baseline, same group)

Quantitative light-induced fluorescence (QLF), fluorescence loss · Patients (mainly children) with white spot lesions (WSL)

Compared with baseline, CPP-ACP significantly improved white spot lesions on QLF (SMD -0.43, 95% CI -0.79 to -0.07; ungraded).

1 finding from 1 review

CPP-ACP vs Placebo paste without CPP-ACP (fluoride toothpaste control)

Quantitative light-induced fluorescence (QLF), fluorescence loss · Patients (mainly children) with white spot lesions (WSL)

CPP-ACP toothpaste did not differ significantly from placebo paste (fluoride control) for white spot lesion remineralization on QLF (MD 0.08, 95% CI -0.91 to 1.08; ungraded).

1 finding from 1 review

Fluorides combined with CPP-ACP vs Fluorides alone (monotherapy)

Quantitative light-induced fluorescence (QLF) change · Patients with early caries lesions in permanent teeth (non-fluoridated water area)

Adding CPP-ACP to fluorides did not significantly change QLF outcomes for smooth-surface early caries lesions versus fluorides alone; not GRADE-rated.

1 finding from 1 review

Quantitative light-induced fluorescence (QLF) vs Reference standard (histology, excavation, or enhanced visual examination)

Diagnostic odds ratio (DOR) for detection of early enamel caries (D1 threshold) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review