Findings

What do systematic reviews say?

116 questions · 117 findings · 13 reviews · Schizophrenia

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No studies found 24 · 20.5%GRADE not reported 14 · 12%Very low 20 · 17.1%Low 32 · 27.4%Moderate 27 · 23.1%High 0 · 0%

QUETIAPINE vs ARIPIPRAZOLE

Mental state · schizophrenia

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 297 participants
Low

QUETIAPINE vs CLOZAPINE ‐ all data short term

Mental state: 3. Negative symptoms ‐ average endpoint score PANSS negative subscore · schizophrenia

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 142 participants
Low

QUETIAPINE vs CLOZAPINE ‐ all data short term

Quality of life: substantial improvement · schizophrenia

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

QUETIAPINE vs CLOZAPINE ‐ all data short term

Adverse effects: 1. Sedation · schizophrenia

QUETIAPINE probably leads to lower adverse effects: 1. Sedation compared with CLOZAPINE ‐ all data short term (moderate certainty).

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
RR 0.22 [0.11, 0.47]
2 studies · 135 participants
Moderate

QUETIAPINE vs CLOZAPINE ‐ all data short term

Adverse effects: 2. Extrapyramidal effects ‐ use of antiparkinson medication · schizophrenia

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
Low

QUETIAPINE vs CLOZAPINE ‐ all data short term

Weight gain · schizophrenia

QUETIAPINE showed no clear difference in adverse effects: 3. Metabolic ‐ weight gain compared with CLOZAPINE ‐ all data short term (low certainty).

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
RR 0.53 [0.25, 1.11]
2 studies · 135 participants
Low

QUETIAPINE vs OLANZAPINE

Clinical response: mean score/change in mental state: mean PANSS total score (high = poor) · schizophrenia

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 1486 participants
Low

QUETIAPINE vs OLANZAPINE

Mental state: 2. Positive symptoms ‐ average endpoint score PANSS positive subscore · schizophrenia

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 801 participants
Moderate

QUETIAPINE vs OLANZAPINE

Mental state: 3. Negative symptoms ‐ average endpoint score PANSS negative subscore · schizophrenia

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 801 participants
Moderate

QUETIAPINE vs OLANZAPINE

Quality of life (medium term: 12 months) · schizophrenia

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 286 participants
Moderate

QUETIAPINE vs OLANZAPINE

Adverse effects: 1. Sedation · schizophrenia

QUETIAPINE showed no clear difference in adverse effects: 1. Sedation compared with OLANZAPINE (moderate certainty).

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
RR 0.98 [0.84, 1.13]
7 studies · 1615 participants
Moderate

QUETIAPINE vs ARIPIPRAZOLE

Mental state: 2. Positive symptoms ‐ average endpoint score PANSS positive subscore · schizophrenia

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 297 participants
Low

QUETIAPINE vs OLANZAPINE

Adverse effects: 2. Extrapyramidal effects ‐ use of antiparkinson medication · schizophrenia

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 1127 participants
Moderate

QUETIAPINE vs OLANZAPINE

Adverse effects: 3. Metabolic ‐ weight significant gain · schizophrenia

QUETIAPINE probably leads to lower adverse effects: 3. Metabolic ‐ weight significant gain compared with OLANZAPINE (moderate certainty).

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
RR 0.69 [0.51, 0.95]
7 studies · 1321 participants
Moderate

QUETIAPINE vs PALIPERIDONE

Mental state · schizophrenia

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 319 participants
Moderate

QUETIAPINE vs PALIPERIDONE

Mental state: 2. Positive symptoms ‐ average endpoint score PANSS positive subscore · schizophrenia

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 319 participants
Moderate

QUETIAPINE vs PALIPERIDONE

Mental state: 3. Negative symptoms ‐ average endpoint score PANSS negative subscore · schizophrenia

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 319 participants
Moderate

QUETIAPINE vs PALIPERIDONE

Quality of life: substantial improvement · schizophrenia

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

QUETIAPINE vs PALIPERIDONE

Adverse effects: 1. Sedation · schizophrenia

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

QUETIAPINE vs PALIPERIDONE

Adverse effects: 2. Extrapyramidal effects ‐ use of antiparkinson medication · schizophrenia

QUETIAPINE probably leads to lower adverse effects: 2. Extrapyramidal effects use of antiparkinson… compared with PALIPERIDONE (moderate certainty).

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
RR 0.64 [0.45, 0.91]
1 study · 319 participants
Moderate