Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

52 questions · 52 findings · 5 reviews

No studies found 1 · 1.9%GRADE not reported 10 · 19.2%Very low 9 · 17.3%Low 20 · 38.5%Moderate 6 · 11.5%High 6 · 11.5%

Balanced protein and energy supplementation vs no intervention or control intervention (control)

Small‐for‐gestational age · pregnant women

Balanced protein and energy supplementation probably leads to lower small‐for‐gestational age compared with control or no intervention (moderate certainty).

1 finding from 1 review

Vitamin D vs placebo or control

High density lipoprotein · Adults (general population)

Meta-analysis of randomised trials of vitamin D supplementation for High density lipoprotein: WMD -0.14 (95% CI -0.99 to 0.71), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.

1 finding from 1 review

Vitamin D vs placebo or control

Serum low‐density lipoprotein (LDL, mmol/L) · Adults (general population)

Meta-analysis of randomised trials of vitamin D supplementation for Low density lipoprotein: WMD 3.23 (95% CI 0.55 to 5.9), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.

1 finding from 1 review