What do systematic reviews say?

Preoperative blood transfusion vs no transfusion

• Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 434 participants
  GRADE not reported

Preoperative blood transfusion vs no transfusion

It is very uncertain whether preoperative blood transfusion changes serious complications related to SCD ‐ painful crises compared with no transfusion (very low certainty).

• Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
  OR 1.91 [0.61, 6.04]
  2 studies · 434 participants
  Very low

Preoperative blood transfusion vs no transfusion

It is very uncertain whether preoperative blood transfusion changes serious infection compared with no transfusion (very low certainty).

• Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
  OR 1.29 [0.29, 5.71]
  2 studies · 434 participants
  Very low

Preoperative blood transfusion vs no transfusion

Preoperative blood transfusion showed no clear difference in perioperative complications ‐ any surgery‐related compared with no transfusion (low certainty).

• Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
  RR 0.24 [0.03, 2.05]
  1 study · 65 participants
  Low

Preoperative blood transfusion vs no transfusion

• Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 19 participants
  GRADE not reported

Preoperative blood transfusion vs no transfusion

• Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 434 participants
  GRADE not reported

Preoperative blood transfusion vs no transfusion

• Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 434 participants
  Very low

Aggressive vs conservative blood transfusion

It is very uncertain whether aggressive changes transfusion‐related complications ‐ cholecystectomy complications… compared with conservative blood transfusion (very low certainty).

• Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
  RR 1.85 [0.89, 3.88]
  1 study · 230 participants
  Very low

Iron therapy vs No treatment, placebo, usual care, or another oral care measure

Iron therapy showed no clear difference in proportion of participants who received a blood transfusion compared with placebo, no treatment or standard care (low certainty).

• Iron therapy for preoperative anaemia 2019 · Cochrane Headline outcomes only
  RR 1.21 [0.87, 1.7]
  4 studies · 200 participants
  Low

Intravenous iron vs oral iron

The review found no eligible studies for this question.

• Iron therapy for preoperative anaemia 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

GnRHa treatment vs placebo or no pretreatment

GnRHa treatment showed no clear difference in blood transfusions compared with no pretreatment or placebo before myomectomy (operative and… (low certainty).

• Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
  OR 0.85 [0.26, 2.75]
  4 studies · 121 participants
  Low
• Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
• Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
  OR 0.54 [0.29, 1.01]
  6 studies · 601 participants
  Moderate

Aggressive vs conservative blood transfusion

• Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 230 participants
  GRADE not reported

Aggressive vs conservative blood transfusion

It is very uncertain whether aggressive changes serious complications related to SCD ‐ cholecystectomy ACS compared with conservative blood transfusion (very low certainty).

• Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
  RR 0.84 [0.38, 1.84]
  1 study · 230 participants
  Very low

Aggressive vs conservative blood transfusion

It is very uncertain whether aggressive changes serious complications related to SCD ‐ cholecystectomy painful crisis compared with conservative blood transfusion (very low certainty).

• Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
  RR 0.3 [0.09, 1.04]
  1 study · 230 participants
  Very low

Aggressive vs conservative blood transfusion

It is very uncertain whether aggressive changes serious infection ‐ cholecystectomy compared with conservative blood transfusion (very low certainty).

• Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
  RR 1.75 [0.59, 5.18]
  1 study · 230 participants
  Very low

Aggressive vs conservative blood transfusion

It is very uncertain whether aggressive changes perioperative complications ‐ cholecystectomy complications (any) compared with conservative blood transfusion (very low certainty).

• Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
  RR 0.75 [0.36, 1.55]
  1 study · 230 participants
  Very low

Aggressive vs conservative blood transfusion

The review found no eligible studies for this question.

• Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found