Findings

What do systematic reviews say?

553 questions · 561 findings · 75 reviews · Cystic Fibrosis and Genetic Disorders · Headline outcomes only

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No studies found 133 · 23.7%GRADE not reported 17 · 3%Very low 145 · 25.8%Low 155 · 27.6%Moderate 94 · 16.8%High 17 · 3%

Exercise prescription plus the use of a wearable fitness tracker vs exercise

FEV1 % predicted · adults with CF

1 finding from 1 review

Digital technology for delivering and monitoring exercise programs for people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Very low

Intervention not reported

SCD knowledge:children Pre‐ and post‐knowledge assessment Duration of · patients with sickle cell disease

1 finding from 1 review

Interventions for patients and caregivers to improve knowledge of sickle cell disease and recognition of its related… 2016 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 160 participants
Moderate

Intervention not reported

SCD knowledge: caregiver Pre‐ and post‐knowledge assessment Duration of · caregivers of patients with sickle cell disease

1 finding from 1 review

Interventions for patients and caregivers to improve knowledge of sickle cell disease and recognition of its related… 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 39 participants
Low

Intervention not reported

Family relationship Pre‐intervention and post‐intervention assessment Home visits and training session for family members Patient‐caregiver relationships assessed pre‐intervention and immediately post‐intervention. · caregivers of patients with sickle cell disease

1 finding from 1 review

Interventions for patients and caregivers to improve knowledge of sickle cell disease and recognition of its related… 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 76 participants
Moderate

Summary of findings: inhaled TOBI® (IV preparation) vs tobramycin

FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

1 finding from 1 review

Inhaled anti‐pseudomonal antibiotics for long‐term therapy in cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 32 participants
Very low

Summary of findings: inhaled TOBI® (IV preparation) vs tobramycin

FVC (% predicted) Change from baseline · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

1 finding from 1 review

Inhaled anti‐pseudomonal antibiotics for long‐term therapy in cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 32 participants
Very low

Exercise prescription plus the use of a wearable fitness tracker vs exercise

Adherence to exercise training (long term) · adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Digital technology for delivering and monitoring exercise programs for people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Exercise prescription plus the use of a wearable fitness tracker vs exercise

Self‐management behavior (long term) · adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Digital technology for delivering and monitoring exercise programs for people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Exercise prescription plus the use of a wearable fitness tracker vs exercise

Time to next pulmonary exacerbation · adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Digital technology for delivering and monitoring exercise programs for people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Exercise prescription plus the use of a wearable fitness tracker vs exercise

Usability of digital health technology (medium term) · adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Digital technology for delivering and monitoring exercise programs for people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Exercise prescription plus the use of a wearable fitness tracker vs exercise

QoL · adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Digital technology for delivering and monitoring exercise programs for people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Exercise prescription plus the use of a wearable fitness tracker vs exercise

Exercise capacity · adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Digital technology for delivering and monitoring exercise programs for people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Autogenic drainage vs PEP

Participant preference · adults and children with CF

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Low

Preoperative blood transfusion vs no transfusion

Serious complications related to SCD ‐ painful crises · people with SCD

It is very uncertain whether preoperative blood transfusion changes serious complications related to SCD ‐ painful crises compared with no transfusion (very low certainty).

1 finding from 1 review

Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
OR 1.91 [0.61, 6.04]
2 studies · 434 participants
Very low

Preoperative blood transfusion vs no transfusion

Serious infection · people with SCD

It is very uncertain whether preoperative blood transfusion changes serious infection compared with no transfusion (very low certainty).

1 finding from 1 review

Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
OR 1.29 [0.29, 5.71]
2 studies · 434 participants
Very low

Preoperative blood transfusion vs no transfusion

Perioperative complications ‐ any surgery‐related · people with SCD

Preoperative blood transfusion showed no clear difference in perioperative complications ‐ any surgery‐related compared with no transfusion (low certainty).

1 finding from 1 review

Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.24 [0.03, 2.05]
1 study · 65 participants
Low

Preoperative blood transfusion vs no transfusion

Transfusion related complications ‐ any · people with SCD

1 finding from 1 review

Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 434 participants
GRADE not reported

Preoperative blood transfusion vs no transfusion

Quality of life · people with SCD

1 finding from 1 review

Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 19 participants
GRADE not reported

Preoperative blood transfusion vs no transfusion

All‐cause mortality · people with SCD

1 finding from 1 review

Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 434 participants
GRADE not reported

Preoperative blood transfusion vs no transfusion

Serious complications related to SCD ‐ ACS · people with SCD

1 finding from 1 review

Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 434 participants
Very low