Findings

What do systematic reviews say?

322 questions · 324 findings · 25 reviews · Eyes and Vision

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No studies found 77 · 23.8%GRADE not reported 5 · 1.5%Very low 77 · 23.8%Low 64 · 19.8%Moderate 91 · 28.1%High 10 · 3.1%

Intervention not reported

Systemic 7‐methylxanthine vs placebo · children with myopia (nearsightedness)

1 finding from 1 review

Interventions to slow progression of myopia in children 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 77 participants
Moderate

Intervention not reported

Atropine plus multifocal spectacles vs placebo plus SVLs · children with myopia (nearsightedness)

1 finding from 1 review

Interventions to slow progression of myopia in children 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 191 participants
Moderate

Intervention not reported

Antimuscarinic agents vs placebo · children with myopia (nearsightedness)

1 finding from 1 review

Interventions to slow progression of myopia in children 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 629 participants
Moderate

Intervention not reported

3,4‐DAP (20 mg, single dose) versus placebo. Assessments made 30 minutes after taking the drug or placebo · people with acquired nystagmus

1 finding from 1 review

Interventions for eye movement disorders due to acquired brain injury 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Very low

Intervention not reported

Control: placebo drops · participants undergoing cataract surgery

1 finding from 1 review

Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery 2017 · Cochrane Headline outcomes only
no estimate extracted
16603 participants
Moderate

Antibiotics vs placebo

Clinical efficacy (RR > 1 is favored) · Participants with acute bacterial conjunctivitis

1 finding from 1 review

Antibiotics versus placebo for acute bacterial conjunctivitis 2023 · Cochrane Headline outcomes only
no estimate extracted
4 participants
Moderate

Antibiotics vs placebo

Microbiological efficacy (RR > 1 favored) · Participants with acute bacterial conjunctivitis

1 finding from 1 review

Antibiotics versus placebo for acute bacterial conjunctivitis 2023 · Cochrane Headline outcomes only
no estimate extracted
8 participants
Moderate

Antibiotics vs placebo

Treatment incompletion (RR < 1 favored) · Participants with acute bacterial conjunctivitis

Antibiotics probably leads to lower treatment incompletion (RR < 1 favored) compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics versus placebo for acute bacterial conjunctivitis 2023 · Cochrane Headline outcomes only
RR 0.64 [0.52, 0.78]
13 studies · 5573 participants
Moderate

Antibiotics vs placebo

Persistent clinical infection after one course of treatment (RR < 1 favored) · Participants with acute bacterial conjunctivitis

Antibiotics probably leads to lower persistent clinical infection after one course of treatment (RR < 1… compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics versus placebo for acute bacterial conjunctivitis 2023 · Cochrane Headline outcomes only
RR 0.73 [0.65, 0.81]
19 studies · 5280 participants
Moderate

Antibiotics vs placebo

Cost‐effectiveness of treatment · Participants with acute bacterial conjunctivitis

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotics versus placebo for acute bacterial conjunctivitis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antibiotics vs placebo

Treatment‐associated ocular complications (RR < 1 or RD ≤ 0 favored) · Participants with acute bacterial conjunctivitis

It is very uncertain whether antibiotics changes treatment‐associated ocular complications (RR < 1 or RD ≤ 0 favored) compared with placebo (very low certainty).

1 finding from 1 review

Antibiotics versus placebo for acute bacterial conjunctivitis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Antibiotics vs placebo

Treatment‐associated systemic complications (RR < 1 favored) · Participants with acute bacterial conjunctivitis

1 finding from 1 review

Antibiotics versus placebo for acute bacterial conjunctivitis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Emixustat vs placebo

Change in BCVA from baseline to 24 months · adults with GA due to AMD

1 finding from 1 review

Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy due to… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 320 participants
Low

Fenretinide vs placebo

Proportion of participants losing ≥ 10 EDTRS letters · adults with GA due to AMD

The review found no eligible studies for this question.

1 finding from 1 review

Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy due to… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fenretinide vs placebo

Progression of geographic atrophy · adults with GA due to AMD

1 finding from 1 review

Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy due to… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 142 participants
Low

Fenretinide vs placebo

Advanced AMD · adults with GA due to AMD

The review found no eligible studies for this question.

1 finding from 1 review

Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy due to… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fenretinide vs placebo

Mean change in macular sensitivity · adults with GA due to AMD

The review found no eligible studies for this question.

1 finding from 1 review

Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy due to… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fenretinide vs placebo

Adverse events · adults with GA due to AMD

1 finding from 1 review

Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy due to… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 246 participants
Low

Emixustat vs placebo

Proportion of participants losing ≥ 15 EDTRS letters · adults with GA due to AMD

Emixustat showed no clear difference in proportion of participants losing ≥ 15 EDTRS letters at 24 months** compared with placebo (low certainty).

1 finding from 1 review

Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy due to… 2020 · Cochrane Headline outcomes only
RR 0.91 [0.59, 1.4]
1 study · 498 participants
Low

Emixustat vs placebo

Proportion of participants losing ≥ 10 EDTRS letters · adults with GA due to AMD

The review found no eligible studies for this question.

1 finding from 1 review

Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy due to… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found