Findings

What do systematic reviews say?

125 questions · 125 findings · 5 reviews · Kidney and Transplant

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No studies found 51 · 40.8%GRADE not reported 0 · 0%Very low 28 · 22.4%Low 36 · 28.8%Moderate 7 · 5.6%High 3 · 2.4%

Pharmacological interventions vs placebo

GABA analogue VAS(0 to 10 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 297 participants
High

Pharmacological interventions vs placebo

Montelukast Duo score (0 to 81) and VAS (0 to 10 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 87 participants
Moderate

Pharmacological interventions vs placebo

Sertraline VAS(0 to 10 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 46 participants
Low

Pharmacological interventions vs placebo

Lidocaine Itch relief · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Very low

Pharmacological interventions vs placebo

Sodium thalidomide Itch relief · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 33 participants
Very low

Pharmacological interventions vs placebo

Doxepin Itch relief · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 48 participants
Low

Pharmacological interventions vs placebo

Ondansetron VAS(0 to 10 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 183 participants
High

Pharmacological interventions vs placebo

Kappa‐opioid agonist VAS(0 to 10 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 661 participants
High

Pharmacological interventions vs placebo

Mu‐opioid antagonist VAS(0 to 10 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 62 participants
Low

Pharmacological interventions vs placebo

Nalbuphine VAS(0 to 10 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 179 participants
Low

Pharmacological interventions vs placebo

Cromolyn VAS(0 to 10 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Low

Pharmacological interventions vs placebo

Nicotinamide VAS(0 to 5 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Pharmacological interventions vs placebo

EPO Duo score(0 to 40) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Pharmacological interventions vs placebo

Cholestyramine 0 to 3 severity scale · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 15 participants
Low

Unfractionated heparin vs no pharmacological anticoagulation

Major bleeding · CRRT

It is very uncertain whether unfractionated heparin changes major bleeding compared with no pharmacological anticoagulation (very low certainty).

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
RR 0.5 [0.05, 4.67]
1 study · 10 participants
Very low