What do systematic reviews say?

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

It is very uncertain whether perioperative restrictive fluid therapy changes major complications (during longest compared with goal‐directed fluid therapy (very low certainty).

• Perioperative restrictive versus goal‐directed fluid therapy for adults undergoing major non‐cardiac surgery 2019 · Cochrane Headline outcomes only
  RR 1.61 [0.78, 3.34]
  5 studies · 484 participants
  Very low

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

It is very uncertain whether perioperative restrictive fluid therapy changes all‐cause mortality (during longest compared with goal‐directed fluid therapy (very low certainty).

• Perioperative restrictive versus goal‐directed fluid therapy for adults undergoing major non‐cardiac surgery 2019 · Cochrane Headline outcomes only
  RD 0.03 [0, 0.06]
  6 studies · 544 participants
  Very low

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

It is very uncertain whether perioperative restrictive fluid therapy changes length of hospital stay (days) compared with goal‐directed fluid therapy (very low certainty).

• Perioperative restrictive versus goal‐directed fluid therapy for adults undergoing major non‐cardiac surgery 2019 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 464 participants
  Very low

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

It is very uncertain whether perioperative restrictive fluid therapy changes surgery‐related complications (during longest compared with goal‐directed fluid therapy (very low certainty).

• Perioperative restrictive versus goal‐directed fluid therapy for adults undergoing major non‐cardiac surgery 2019 · Cochrane Headline outcomes only
  RR 1.54 [0.87, 2.72]
  4 studies · 364 participants
  Very low

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

It is very uncertain whether perioperative restrictive fluid therapy changes non‐surgery‐related complications (during longest compared with goal‐directed fluid therapy (very low certainty).

• Perioperative restrictive versus goal‐directed fluid therapy for adults undergoing major non‐cardiac surgery 2019 · Cochrane Headline outcomes only
  RR 1 [0.52, 1.93]
  1 study · 74 participants
  Very low

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

It is very uncertain whether perioperative restrictive fluid therapy changes renal failure (during longest compared with goal‐directed fluid therapy (very low certainty).

• Perioperative restrictive versus goal‐directed fluid therapy for adults undergoing major non‐cardiac surgery 2019 · Cochrane Headline outcomes only
  RR 1.38 [0.57, 3.36]
  4 studies · 410 participants
  Very low

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

• Perioperative restrictive versus goal‐directed fluid therapy for adults undergoing major non‐cardiac surgery 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 74 participants
  Very low