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What do systematic reviews say?

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Evidence found and GRADE certainty

18 questions · 18 findings · 3 reviews · Vascular · Headline outcomes only

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No studies found 5 · 27.8%GRADE not reported 0 · 0%Very low 6 · 33.3%Low 5 · 27.8%Moderate 2 · 11.1%High 0 · 0%

Cilostazol vs pentoxifylline

Adverse event related to study medication ‐ headache (number of cases) · intermittent claudication

Cilostazol may leads to higher adverse event related to study medication ‐ headache (number of cases) compared with pentoxifylline (low certainty).

1 finding from 1 review

Prostanoids vs pentoxifylline

Adverse events (participants) · people with critical limb ischaemia

It is very uncertain whether prostanoids changes adverse events (participants) compared with pentoxifylline (very low certainty).

1 finding from 1 review

Prostanoids vs pentoxifylline

Rest‐pain relief · people with critical limb ischaemia

It is very uncertain whether prostanoids changes rest‐pain relief compared with pentoxifylline (very low certainty).

1 finding from 1 review

Prostanoids vs pentoxifylline

Ulcer healing · people with critical limb ischaemia

It is very uncertain whether prostanoids changes ulcer healing compared with pentoxifylline (very low certainty).

1 finding from 1 review

Prostanoids vs pentoxifylline

Amputation · people with critical limb ischaemia

It is very uncertain whether prostanoids changes total amputations compared with pentoxifylline (very low certainty).

1 finding from 1 review