Findings

What do systematic reviews say?

11 questions · 12 findings · 3 reviews · Headline outcomes only

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No studies found 2 · 16.7%GRADE not reported 0 · 0%Very low 1 · 8.3%Low 2 · 16.7%Moderate 4 · 33.3%High 3 · 25%

Paracetamol 1000 mg vs placebo

Pain‐free at 2 hours · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Paracetamol 1000 mg vs placebo

Pain‐free at 1 hour · adults with episodic tension‐type headache

2 findings from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate
Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Paracetamol 1000 mg vs placebo

Use of rescue medication · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Paracetamol 1000 mg vs placebo

Pain‐free or mild pain at 2 hours · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Paracetamol 1000 mg vs placebo

Any adverse event · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Paracetamol 1000 mg vs placebo

Serious adverse events · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Summary of findings table ‐ Intravenous paracetamol 1000 mg vs 2 pumps of cervical lidocaine spray

Pain with dilation ‐ not measured · people requesting a surgical abortion at 5+0 to 7+0 weeks' gestation

The review found no eligible studies for this question.

1 finding from 1 review

Local anaesthesia for pain control in first trimester surgical abortion 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Intravenous paracetamol 1000 mg vs 2 pumps of cervical lidocaine spray

Pain with aspiration ‐ not measured · people requesting a surgical abortion at 5+0 to 7+0 weeks' gestation

The review found no eligible studies for this question.

1 finding from 1 review

Local anaesthesia for pain control in first trimester surgical abortion 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Intravenous paracetamol 1000 mg vs 2 pumps of cervical lidocaine spray

Pain during procedurea,b · people requesting a surgical abortion at 5+0 to 7+0 weeks' gestation

1 finding from 1 review

Local anaesthesia for pain control in first trimester surgical abortion 2024 · Cochrane Headline outcomes only
no estimate extracted
1 study · 48 participants
Low

Cysteamine vs no intervention

Hepatotoxicity (aspartate aminotransferase > 1000 IU/L) · people with paracetamol (acetaminophen) overdose

Cysteamine may leads to lower hepatotoxicity (aspartate aminotransferase > 1000 IU/L) compared with no intervention (low certainty).

1 finding from 1 review

Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
OR 0.09 [0.02, 0.35]
2 studies · 65 participants
Low

Cysteamine vs methionine (randomised trials)

Hepatotoxicity (aspartate aminotransferase > 1000 IU/L) · people with paracetamol (acetaminophen) overdose

It is very uncertain whether cysteamine changes hepatotoxicity (aspartate aminotransferase > 1000 U/L) compared with methionine (randomised trials) (very low certainty).

1 finding from 1 review

Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
OR 0.92 [0.05, 16.46]
1 study · 27 participants
Very low