Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

121 questions · 121 findings · 7 reviews · Pain, Palliative and Supportive Care

No studies found 50 · 41.3%GRADE not reported 4 · 3.3%Very low 24 · 19.8%Low 36 · 29.8%Moderate 6 · 5%High 1 · 0.8%

Hospital‐based specialist palliative care vs usual care

Achieving patient preferred place of death (measured by number of patients with home death) · adults with advanced illness and their unpaid caregivers/families

Hospital‐based specialist palliative care may leads to higher achieving patient preferred place of death (measured by number of… compared with usual care (low certainty).

1 finding from 1 review

Naldemedine vs placebo

Laxation response: risk of spontaneous rescue‐free bowel movements in the short terma · people with cancer irrespective of whether receiving palliative care and with opioid‐induced bowel dysfunction

The review found no eligible studies for this question.

1 finding from 1 review

Low dose naldemedine vs higher dose

Symptoms of opioid withdrawal in the medium term · people with cancer irrespective of whether receiving palliative care and with opioid‐induced bowel dysfunction

Low dose naldemedine showed no clear difference in symptoms of opioid withdrawalfin the medium termb compared with higher doses (low certainty).

1 finding from 1 review

Low dose naldemedine vs higher dose

Serious adverse eventsg · people with cancer irrespective of whether receiving palliative care and with opioid‐induced bowel dysfunction

Low dose naldemedine showed no clear difference in serious adverse eventsg compared with higher doses (low certainty).

1 finding from 1 review

Low dose naldemedine vs higher dose

Adverse events · people with cancer irrespective of whether receiving palliative care and with opioid‐induced bowel dysfunction

Low dose naldemedine showed no clear difference in adverse events compared with higher doses (low certainty).

1 finding from 1 review