Acceptance and commitment therapy (ACT) showed no clear difference in abstinence from drug use at 6 months compared with waiting list control (low certainty).
Selective serotonin reuptake inhibitor antidepressant showed no clear difference in participants abstinent at end of treatment compared with placebo (low certainty).
It is very uncertain whether selective serotonin reuptake inhibitor antidepressant changes participants experiencing adverse effects compared with placebo (very low certainty).
It is very uncertain whether selective serotonin reuptake inhibitor antidepressant changes participants withdrawn due to adverse effects compared with placebo (very low certainty).
It is very uncertain whether selective serotonin reuptake inhibitor antidepressant changes completion of scheduled treatment compared with placebo (very low certainty).
Antidepressants showed no clear difference in acceptability: dropouts compared with placebo: all studies (low certainty).