Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Emergency and Critical Care

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No studies found 1 · 16.7%GRADE not reported 0 · 0%Very low 1 · 16.7%Low 3 · 50%Moderate 1 · 16.7%High 0 · 0%

PCT vs non‐PCT (standard care or CRP: primary outcomes)

Has died · adult patients with sepsis, severe sepsis and septic shock

PCT showed no clear difference in mortality at longest compared with non‐PCT (standard care or CRP: primary outcomes) (low certainty).

1 finding from 1 review

Effectiveness and safety of procalcitonin evaluation for reducing mortality in adults with sepsis, severe sepsis or… 2017 · Cochrane Headline outcomes only
RR 0.81 [0.65, 1.01]
10 studies · 1156 participants
Low

PCT vs non‐PCT (standard care or CRP: primary outcomes)

Mortality at 28 days · adult patients with sepsis, severe sepsis and septic shock

PCT showed no clear difference in mortality at 28 days compared with non‐PCT (standard care or CRP: primary outcomes) (low certainty).

1 finding from 1 review

Effectiveness and safety of procalcitonin evaluation for reducing mortality in adults with sepsis, severe sepsis or… 2017 · Cochrane Headline outcomes only
RR 0.89 [0.61, 1.31]
4 studies · 316 participants
Low

PCT vs non‐PCT (standard care or CRP: primary outcomes)

Mortality at ICU discharge · adult patients with sepsis, severe sepsis and septic shock

PCT showed no clear difference in mortality at ICU discharge compared with non‐PCT (standard care or CRP: primary outcomes) (low certainty).

1 finding from 1 review

Effectiveness and safety of procalcitonin evaluation for reducing mortality in adults with sepsis, severe sepsis or… 2017 · Cochrane Headline outcomes only
RR 1.03 [0.5, 2.11]
3 studies · 506 participants
Low

PCT vs non‐PCT (standard care or CRP: primary outcomes)

Death at hospital discharge · adult patients with sepsis, severe sepsis and septic shock

PCT showed no clear difference in mortality at hospital discharge compared with non‐PCT (standard care or CRP: primary outcomes) (moderate certainty).

1 finding from 1 review

Effectiveness and safety of procalcitonin evaluation for reducing mortality in adults with sepsis, severe sepsis or… 2017 · Cochrane Headline outcomes only
RR 0.98 [0.75, 1.27]
7 studies · 805 participants
Moderate

PCT vs non‐PCT (standard care or CRP: primary outcomes)

Time receiving antimicrobial therapy (days) ‐ mean (SD) · adult patients with sepsis, severe sepsis and septic shock

1 finding from 1 review

Effectiveness and safety of procalcitonin evaluation for reducing mortality in adults with sepsis, severe sepsis or… 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 313 participants
Very low

PCT vs non‐PCT (standard care or CRP: primary outcomes)

Participants with antimicrobial regimen changed from a broad to a narrower spectrum · adult patients with sepsis, severe sepsis and septic shock

The review found no eligible studies for this question.

1 finding from 1 review

Effectiveness and safety of procalcitonin evaluation for reducing mortality in adults with sepsis, severe sepsis or… 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found